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Table 1 Baseline clinical and laboratorial characteristics among 5050 participants according to quartiles of GlycA

From: GlycA, a marker of protein glycosylation, is related to albuminuria and estimated glomerular filtration rate: the ELSA-Brasil study

 

Quartile 1 GlycA ≤368 n=1262

Quartile 2 GlycA ≥369 - ≤410 n=1259

Quartile 3 GlycA ≥411 - ≤456 n=1266

Quartile 4 GlycA ≥457 n=1263

p**

Age (years; mean/std)

52

9

51

9

51

9

52

9

0.09

Sex (male; n / %)

702

0.56

602

0.48

548

0.43

472

0.37

< 0.001

Smoking status

        

< 0.001

 Never (n/%)

752

0.60

672

0.53

665

0.53

574

0.45

 

 Former (n/%)

383

0.30

390

0.31

374

0.30

419

0.33

 

 Current (n/%)

127

0.10

197

0.16

227

0.18

270

0.21

 

Alcohol

        

< 0.001

 Never (n/%)

120

0.10

130

0.10

164

0.13

189

0.15

 

 Former (n/%)

242

0.19

224

0.18

268

0.21

288

0.23

 

 Current (n/%)

899

0.71

904

0.72

834

0.66

786

0.62

 

Diabetes mellitus (n/%)

173

0.14

215

0.17

263

0.21

401

0.32

< 0.001

Self-reported myocardial infarction (n/%)

20

0.02

21

0.02

17

0.01

38

0.03

0.01

Self-reported CVD (n/%)

73

0.06

75

0.06

59

0.05

108

0.09

0.001

Self-reported stroke (n/%)

15

0.01

14

0.01

8

0.01

25

0.02

0.02

Body-mass index (kg/m2; mean/std)

25.5

4.3

26.9

4.3

27.9

4.6

29.3

5.5

< 0.001

Waist-to-hip ratio (mean/std)

.87

.09

.89

.09

.90

.08

.91

.09

< 0.001

Systolic blood pressure (mmHg; mean/std)

116.4

15.1

119.2

16.8

120.4

16.0

123.3

17.7

< 0.001

Diastolic blood pressure (mmHg; mean/std)

72.4

10.2

74.6

10.9

75.9

10.2

77.9

11.1

< 0.001

Leptin (ng/mL)

9.64

5.4–16.6

12.23

6.2–21.4

14.43

7.0–26.8

15.19

8.7–28.2

< 0.001

Hemoglobin (g/dL; mean/std)

14.5

1.4

14.4

1.4

14.3

1.3

14.1

1.4

< 0.001

Hematocrit (%; mean/std)

43.2

3.9

43.0

4.0

42.8

3.7

42.2

4.0

< 0.001

Glucose (mg/dL; mean/std)

106

18

109

25

112

28

120

43

< 0.001

Glucose among non-diabetics (mg/dL; mean/std)

102

8

103

9

104

8

105

8

< 0.001

HbA1C (%; mean/std)

5.2

0.7

5.4

0.9

5.5

0.9

5.8

1.3

< 0.001

Postload glucose 2 h (among non-diabetic, mg/dL; mean/std)

124

36

129

39

137

42

145

51

< 0.001

HOMA index* (median/IQR)

1.3

0.65–2.23

1.6

0.90–2.64

2.0

1.14–3.24

2.4

1.42–3.87

< 0.001

HOMA index among non-diabetics (median/IQR)

1.13

0.61–1.89

1.46

0.83–243

1.69

1.06–2.81

2.04

1.27–3.10

< 0.001

Total cholesterol (mg/dL; mean/std)

205

40

209

39

216

41

221

45

< 0.001

Triglycerides (mg/dL; median/IQR)

108

73

123

63

142

85

179

146

< 0.001

HDL-cholesterol (mg/dL; mean/std)

59

15

57

14

55

13

53

13

< 0.001

LDL-cholesterol (mg/dL; mean/std)

124

32

128

33

133

35

134

36

< 0.001

Uric acid (mg/dL; mean/std)

5.4

1.4

5.6

1.5

5.7

1.5

5.9

1.6

< 0.001

Aspartate Transaminase (AST) (U/L; mean/std)

25

12

26

12

26

17

25

10

< 0.001

Alanine Transaminase (ALT) (U/L; mean/std)

27

18

29

19

29

26

28

15

0.01

Gamma-Glutamyl Transferase (U/L, mean/std)

31

34

35

39

40

54

48

71

< 0.001

Liver right lobe (post_ant diameter) (cm; mean/std)

103

11

105

12

105

11

106

12

< 0.001

Potassio - Sangue (mEq/L)

4.5

0.3

4.6

0.4

4.6

0.3

4.6

0.4

< 0.001

Albumine-to-Creatinine ratio (μg/mg; median/IQR)

6

5–8

7

5–8

7

5–8

7

5–9

< 0.001

Estimated GFR CKD-EPI (ml/min/1.73 m2; mean/std)

83.1

14.3

82.9

15.2

83.0

15.3

81,.5

17.4

0.12

hs-C Reactive Protein (mg/L; mean/std)

1.0

1.2

1.8

1.9

2.8

3.0

6.0

7.3

< 0.001

  1. *excluding insulin-users
  2. **Jonckheere-Terpstra or chi-square tests
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