GlycA, a marker of protein glycosylation, is related to albuminuria and estimated glomerular filtration rate: the ELSA-Brasil study

Table 3 Unadjusted and adjusted logistic regression models on the diagnosis of albuminuria A2 or A3 (versus albuminuria A1), on eGFR < 60 ml/min/1.73m² (versus eGFR > 60 ml/min/1.73m²) and on both (albuminuria or eGFR < 60 ml/min/1.73m²) among 5050 participants

	OR	95%CI OR		p value
Albuminuria A2 or A3 n = 248 (versus albuminuria A1 n = 4590) Per 1 sd increase
Model 1: univariable
GlycA	1.60	1.49	1.72	< 0.0001
Model 2: sex and age adjusted
GlycA	1.64	1.52	1.76	< 0.0001
Model 3: sex, age, HbAlc, SBP and BMI adjusted
GlycA	1.43	1.30	1.56	< 0.0001
Model 4: sex, age, HbA1c, SBP, BMI, smoking, alcohol, LDL, HDL and hsCRP
GlycA	1.46	1.31	1.61	< 0.0001
Model 5: same model 4 + CKDEPI eGFR
GlycA	1.42	1.27	1.57	< 0.0001
CKD EPI eGFR < 60 ml/min/1.73 m ² n = 321 (versus > 60 ml/min/1.73 m2 n = 4519) Per 1 sd increase
Model 1: univariable
GlycA	1.30	1.19	1.41	< 0.0001
Model 2: sex and age adjusted
GlycA	1.33	1.22	1.45	< 0.0001
Model 3: sex, age, HbA1c, SBP and BMI adjusted
GlycA	1.24	1.12	1.36	< 0.0001
Model 4: sex, age, HbA1c, SBP, BMI, smoking, alcohol, LDL, HDL and hsCRP
GlycA	1.32	1.18	1.46	< 0.0001
Model 5: same model 4 + albuminuria
GlycA	1.26	1.12	1.41	.0003
Albuminuria and/or CKD-EPI eGFR < 60 ml/min/1.73 m ² (n = 518 vs. 4433) Per 1 sd increase
Model 1: univariable
GlycA	1.38	1.36	1.45	< 0.0001
Model 2: sex and age adjusted
GlycA	1.45	1.36	1.54	< 0.0001
Model 3: sex, age, HbA1c, SBP and BMI adjusted
GlycA	1.28	1.19	1.38	< 0.0001
Model 4: sex, age, HbA1c, SBP, BMI, smoking, alcohol, LDL, HDL and hsCRP
GlycA	1.35	1.23	1.46	< 0.0001

ISSN: 1471-2369