Concordance between modification of diet in renal disease, chronic kidney disease epidemiology collaboration and Cockcroft-Gault equations in patients with chronic kidney disease at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Dinsa, Hunduma; Nedi, Teshome; Berha, Alemseged Beyene

doi:10.1186/s12882-017-0783-3

Table 3 Specific drugs with drug dose adjustment disagreement between CG and MDRD formula among patients with chronic kidney disease in renal clinic of St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia between July – September, 2016 (n = 17)

From: Concordance between modification of diet in renal disease, chronic kidney disease epidemiology collaboration and Cockcroft-Gault equations in patients with chronic kidney disease at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Drug	Dosing guideline according to Up to date version 21.2	CG (ml/min)			MDRD (ml/min/1.73m²)
Drug	Dosing guideline according to Up to date version 21.2	eCr Cl	Dose	Dose recommendation	eGFR	dose	Dose recommendation
Pyrazinamide 1200 mg tablet orally every 24 h	CrCl < 30 ml/min; 25–35 mg/kg three times per week	27	too high	Decrease	34	Normal	No change
Glyburide 2.5 mg tablet orally every 24 h	CrCl < 50 ml/min; contraindicated	31	CI	D/C	72	Normal	No change
Glyburide 2.5 mg tablet orally every 24 h	CrCl < 50 ml/min; contraindicated	36	CI	D/C	67	Normal	No change
Metformin 500 mg tablet orally every 12 h	CrCl < 60 ml/min; Contraindicated(CI)	43	CI	D/C	72	Normal	No change
		59	CI	D/C	77	Normal	No change
		58	CI	D/C	62	Normal	No change
		55	CI	D/C	73	Normal	No change
		58	CI	D/C	77	Normal	No change
Metformin 500 mg tablet orally every 24 h		39	CI	D/C	69	Normal	No change
Trimethoprim-sulfamethoxazole 960 mg tablet orally every 24 h	CrCl 15–30 ml/min: 50% of recommended dose;CrCl < 15 ml/min:contraindicated	13	CI	D/C	18	too high	decrease by half
		21	too high	decrease by half	38	Normal	No change
		36	Normal	No change	30	too high	decrease by half
Trimethoprim-sulfamethoxazole 480 mg tablet orally every 24 h		24	Normal	No change	32	too low	double it
Ciprofloxacin 500 mg orally every 12 h	CrCl 30–50 ml/min: 250–500 mg orally every 12 h; CrCl 5–29 ml/min: contraindicated	20	too high	decrease interval to every 12 h	31	Normal	No change
Ciprofloxacin 500 mg orally every 12 h		28	too high	decrease interval to every 12 h	31	Normal	No change
Atenolol 50 mg tablet orally every 24 h	CrCl 15–35 ml/min/1.73m²: maximum dose 50 mg every 24 h; CrCl <15 ml/min/1.73m²: maximum dose 25 mg every 24 h	15	Normal	No change	14	too high	decrease by half
Atenolol 50 mg tablet orally every 24 h		14	too high	decrease by half	19	Normal	No change

CI: contraindicated; D/C: discontinue; hrs: hours

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ISSN: 1471-2369

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