Fig. 1

Correlation between creatinine clearance and the plasma aldosterone concentration (left panel), and aldosterone-to-renin ratio (right panel) during placebo and ARB treatment, during a regular sodium intake. Creatinine clearance is significantly and negatively correlated with PAC, and this correlation is similar during placebo and ARB treatment. ARR is similarly, and negatively correlated with creatinine clearance. During RAASi the regression line is parallel and shifted downwards. PAC: plasma aldosterone concentration; ARR: aldosterone-to-renin ratio; ARB: angiotensin receptor blocker (losartan 100 mg/day)