Table 1 Clinical and biochemical parameters during different study periods

Systolic blood pressure (mmHg)

RS

143 (4)

135 (3)^†

125 (3)^†‡

LS

136 (3)*

128 (3)*^†

121 (2)^†‡

Diastolic blood pressure (mmHg)

RS

86 (2)

80 (2)^†

75 (1)^†‡

LS

83 (1)*

78 (1)^†

74 (1)^†‡

Plasma potassium concentration (mmol/l)

RS

4.3 ± 0.1

4.4 ± 0.1

4.0 ± 0.1^†‡

LS

4.3 ± 0.1

4.5 ± 0.1^†

4.0 ± 0.1^†‡

24 h sodium excretion (mmol/day)

RS

200 ± 10

197 ± 11

193 ± 11

LS

89 ± 10*

92 ± 8*

93 ± 8*

Creatinine clearance (ml/min)

RS

85 (73–98)

90 (77–106)

81 (69–95)^‡

LS

80 (67–94)

79 (67–93)*

72 (61–85)*

Proteinuria (g/day)

RS

3.4 (2.6–4.3)

2.3 (1.8–3.0)^†

1.3 (1.0–1.7)^†‡

LS

2.3 (1.7–3.1)*

1.3 (0.9–1.7)^†*

0.9 (0.6–1.2)*^†‡

Active plasma renin concentration (ng AI/ml x h)

RS

15 (12–18)

33 (23–45)^†

64 (47–87)^†‡

LS

19 (15–23)

51 (38–70)*^†

130 (103–163)*^†‡

Plasma aldosterone concentration (ng/l)

RS

66 (48–91)

57 (41–79)

96 (74–125)^‡

LS

106 (73–152)

113 (86–149)*

164 (129–207)*^†‡

Aldosterone-to-renin ratio (ng/ng AI × h)

RS

19 (13–26)

7 (4–11)^†

6 (4–9)^†

LS

22 (14–32)

9 (6–13)^†

5 (4–7)^†‡