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Table 1 Clinical characteristics at diagnosis of patients with ANCA-associated vasculitis and renal involvement with a short and long prodromal phase

From: Relation between duration of the prodromal phase and renal damage in ANCA-associated vasculitis

Clinical characteristics at diagnosis
  Total
n = 72
T ≤ 22 weeks
n = 36
T > 22 weeks
n = 36
p-value
Male sex 74 70 78 0.42
Age, mean ± sd 64 ± 12 66 ± 11 61 ± 13 0.10
Caucasian 96 100 92 0.37
PR3 ANCA 59 56 61 0.63
MPO ANCA 42 44 39 0.63
ANCA-titre ≥4 times cut-off value 85 94 75 0.03
Induction therapy cyclophosphamide and glucocorticoids 75 78 72 0.49
Maintenance therapy azathioprine and glucocorticoids 76 81 72 0.23
Organ involvementa
 Pulmonary 44 50 39 0.34
 ENT 43 31 56 0.03
 Arthritis/arthralgia 40 31 50 0.09
 Neurologic 31 25 36 0.31
 Skin and soft tissue 15 14 17 0.74
Type of AAV
 GPA 64 50 78 0.05
 MPA 32 44 19  
 EGPA 4 6 3  
Renal biopsy proven 44 44 44 1.00
BVAS/WG at diagnosis, median (IQR) 7 (3) 7 (3) 7 (3) 0.71
Erythrocyturiab 75 81 69 0.63
Renal insufficiencyc 79 78 81 0.77
eGFR (ml/min), median (IQR)d 34 (50) 35 (50) 30 (51) 0.84
Proteinuriae 81 75 87 0.21
CCI, median (IQR) 0 (1) 0 (1) 0 (1) 0.67
FFS, median (IQR) 2 (2) 2 (2) 1 (2) 0.12
  1. Data expressed as percentage unless otherwise stated
  2. ANCA antineutrophil cytoplasmic antibody, BVAS/WG Birmingham Vasculitis Activity Score specific for Wegener’s Granulomatosis, CCI Charlson Comorbidity Index, EGPA eosinophilic granulomatosis with polyangiitis, FFS five factors score, GPA granulomatosis with polyangiitis, IQR interquartile range, MPA microscopic polyangiitis, MPO myeloperoxidase, PR3 proteinase 3, sd standard deviation; T ≤ 22 weeks prodromal phase ≤22 weeks, T > 22 weeks prodromale phase >22 weeks
  3. aOrgan involvement at time of diagnosis, in accordance with BVAS/WG
  4. bErythrocyturia was defined as ≥10 erythrocytes per high power field
  5. cRenal insufficiency was defined as a rise in creatinine of >30%
  6. deGFR calculated by the Chronic Kidney Disease Epidemiology Collaboration equation
  7. eProteinuria was defined as ≥0.5 g/24 h or ≥300 mg/l protein in a urine sample