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Table 1 Clinical characteristics at diagnosis of patients with ANCA-associated vasculitis and renal involvement with a short and long prodromal phase

From: Relation between duration of the prodromal phase and renal damage in ANCA-associated vasculitis

Clinical characteristics at diagnosis

 

Total

n = 72

T ≤ 22 weeks

n = 36

T > 22 weeks

n = 36

p-value

Male sex

74

70

78

0.42

Age, mean ± sd

64 ± 12

66 ± 11

61 ± 13

0.10

Caucasian

96

100

92

0.37

PR3 ANCA

59

56

61

0.63

MPO ANCA

42

44

39

0.63

ANCA-titre ≥4 times cut-off value

85

94

75

0.03

Induction therapy cyclophosphamide and glucocorticoids

75

78

72

0.49

Maintenance therapy azathioprine and glucocorticoids

76

81

72

0.23

Organ involvementa

 Pulmonary

44

50

39

0.34

 ENT

43

31

56

0.03

 Arthritis/arthralgia

40

31

50

0.09

 Neurologic

31

25

36

0.31

 Skin and soft tissue

15

14

17

0.74

Type of AAV

 GPA

64

50

78

0.05

 MPA

32

44

19

 

 EGPA

4

6

3

 

Renal biopsy proven

44

44

44

1.00

BVAS/WG at diagnosis, median (IQR)

7 (3)

7 (3)

7 (3)

0.71

Erythrocyturiab

75

81

69

0.63

Renal insufficiencyc

79

78

81

0.77

eGFR (ml/min), median (IQR)d

34 (50)

35 (50)

30 (51)

0.84

Proteinuriae

81

75

87

0.21

CCI, median (IQR)

0 (1)

0 (1)

0 (1)

0.67

FFS, median (IQR)

2 (2)

2 (2)

1 (2)

0.12

  1. Data expressed as percentage unless otherwise stated
  2. ANCA antineutrophil cytoplasmic antibody, BVAS/WG Birmingham Vasculitis Activity Score specific for Wegener’s Granulomatosis, CCI Charlson Comorbidity Index, EGPA eosinophilic granulomatosis with polyangiitis, FFS five factors score, GPA granulomatosis with polyangiitis, IQR interquartile range, MPA microscopic polyangiitis, MPO myeloperoxidase, PR3 proteinase 3, sd standard deviation; T ≤ 22 weeks prodromal phase ≤22 weeks, T > 22 weeks prodromale phase >22 weeks
  3. aOrgan involvement at time of diagnosis, in accordance with BVAS/WG
  4. bErythrocyturia was defined as ≥10 erythrocytes per high power field
  5. cRenal insufficiency was defined as a rise in creatinine of >30%
  6. deGFR calculated by the Chronic Kidney Disease Epidemiology Collaboration equation
  7. eProteinuria was defined as ≥0.5 g/24 h or ≥300 mg/l protein in a urine sample