Fig. 2

Negative response to eculizumab treatment in C3G patients. Graphs show treatment response to eculizumab. Column charts show applied eculizumab dose (low column: 900 mg; high column: 1200 mg). Line charts display serum serum creatinine levels (black; SCr; mg/dl), and urinary protein levels (grey; UPCR; g/g) over time (weeks). a Patient C3GN4. Dashed lines show the period of time (1.5 years) where eculizumab was paused. b Patient DDD2. c Patient C3GN5. Dashed lines show the period of time (17 weeks) where eculizumab was paused