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Table 3 Endotoxin levels in the dialysate and the PVP solution per membrane measured by the LAL-assay (n = 6 for each membrane). LOD was 0.005 EU/ml

From: Assessment of the association between increasing membrane pore size and endotoxin permeability using a novel experimental dialysis simulation set-up

Membrane

Dialysate (EU/ml)

PVPpre (EU/ml)

PVPpost (EU/ml)

Statistics PVPpre vs PVPpost

   

Duplicate 1

Duplicate 2

 

Low-flux

3.5

< LOD

< LOD

< LOD

 

3.9

< LOD

< LOD

< LOD

 

5.5

< LOD

< LOD

< LOD

 

9.4

< LOD

< LOD

< LOD

 

10.3

< LOD

0.011

< LOD

 

19.1

< LOD

< LOD

< LOD

n.s.

Mean ± SD

8.6 ± 5.8

    

High-flux

3.6

< LOD

< LOD

< LOD

 

4.1

0.008

0.007

0.008

 

5.9

< LOD

0.005

< LOD

 

6.1

< LOD

< LOD

< LOD

 

20.0

0.007

< LOD

< LOD

 

33.7

< LOD

< LOD

< LOD

n.s.

Mean ± SD

12.2 ± 12.2

    

Medium cut-off

6.0

< LOD

0.023

0.005

 

6.3

< LOD

< LOD

< LOD

 

6.8

< LOD

< LOD

< LOD

 

8.0

< LOD

0.006

0.005

 

10.6

< LOD

0.005

0.005

 

11.8

< LOD

< LOD

< LOD

n.s.

Mean ± SD

8.3 ± 2.4

    

High cut-off

3.2

< LOD

0.019

0.013

 

4.1

< LOD

0.005

0.005

 

5.4

< LOD

0.005

0.005

 

5.8

< LOD

0.005

< LOD

 

12.1

< LOD

< LOD

< LOD

 

22.5

0.006

0.005

0.005

n.s.

Mean ± SD

8.9 ± 7.4

    
  1. Data with measurable endotoxin levels were written in italic and when they were higher than the PVPpre value they were additionally put in bold and underlined