Fig. 4

Erythrocyte turnover. a Biotinylated erythrocytes significantly decreased in the UNX-Thy1 + Vehicle group compared with in the Sham group. C.E.R.A. treatment in the UNX-Thy1 group significantly suppressed the decrease in biotinylated erythrocytes in circulation. b Although there was no statistical significance, total bilirubin in the plasma of the UNX-Thy1 + Vehicle group tended to increase compared with that in the Sham group. C.E.R.A. treatment in the UNX-Thy1 group tended to decrease plasma total bilirubin. Values are shown as mean ± SEM. *, P < 0.05 (a, two-way ANOVA followed by Tukey’s test; b, Tukey’s test). Sham, n = 5; UNX-Thy1 + Vehicle, n = 6; UNX-Thy1 + C.E.R.A., n = 6