Fig. 2

a Frequency of measures used to define kidney decline/chronic kidney disease progression in 31 longitudinal publications; (b) Frequency of measures used to define albuminuria/proteinuria in 33 longitudinal publications. *100% (3 out of 3) of 50% decline in eGFR, 60% (3 out of 5) of doubling of serum creatinine, and 33% (1 out of 3) of kidney disease progression measures included the composite end points of renal replacement therapy initiation, end-stage renal disease, or mortality. Nephropathy progression did not include composite end points, instead, three studies reported “nephropathy progression” and one reported “worsening of nephropathy stage”. CKD chronic kidney disease, Cr creatinine, eGFR estimated glomerular filtration rate, GFR glomerular filtration rate, s serum