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Fig. 3 | BMC Nephrology

Fig. 3

From: MORG1+/− mice are protected from histological renal damage and inflammation in a murine model of endotoxemia

Fig. 3

a-c: PHD3 renal expression in MORG1+/+ and MORG1+/− mice 24 h after LPS or NaCl application. a Immunohistological detection of renal PHD3 protein expression. Representative images are shown. Original magnification 400×. Bars correspond to 20 μm. b Evaluation of the PHD3 renal immunohistology. The number of the positively stained PHD3 cells per field was counted and is graphically presented. N = 4 mice per treatment, MORG1+/− saline vs. MORG1+/+ saline treated mice, p = 0.006; MORG1+/− LPS vs. MORG1+/+ LPS treated mice, p < 0.001; MORG1+/− LPS vs. MORG1+/− NaCl treated mice, p < 0.001; MORG1+/+ LPS vs. MORG1+/+ saline treated mice, p < 0.001. **p < 0.01, ***p < 0.001. c Renal Phd3 mRNA expression. Real-time PCR assay revealed that MORG1 down-regulation is associated with a reduced basic expression of Phd3 mRNA. *p < 0.05. LPS administration reduced Phd3 expression in MORG1+/+ mice but did not significantly affect Phd3 expression in MORG1 heterozygous mice. N = 6 per group, *p < 0.05

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