Table 2 Comparison of biochemical and immunological data in cases of nephrotic and nephritic syndrome. Figures are presented as mean (SD), median (IQR) and number (%)
From: Proteinuric kidney disease in children at Queen Elizabeth Central Hospital, Malawi
Parameter (reference range) | Nephrotic syndrome | Nephritic syndrome | p-value |
|---|---|---|---|
(n = 15) | (n = 10) | ||
Age, years | 8.4 (3.8) | 7.9 (2.6) | 0.61 |
HIV status | |||
HIV negative | 13 (87%) | 9 (90%) | |
HIV unknown | 2 (13%) | 1 (10%) | |
Albumin (35–50 mg/dl) | |||
Baseline | 13 (8–16) | 25 (22–28) | < 0.001 |
3 months | 36 (18–43) | 38 (30–39) | 0.26 |
Creatinine(0.2–1.1 mg/dl)a | |||
Baseline | 0.6 (0.3–1.5) | 0.8 (0.6–1.7) | 0.22 |
3 months | 0.9 (0.2–1.0) | 0.6 (0.3–1.0) | 0.79 |
eGFR (65–135 ml/min/1.73m2)a | |||
Baseline | 100 (47–175) | 40 (34–95) | 0.95 |
3 months | 95 (73–275) | 116 (49–164) | 0.83 |
Complement C3 (0.88–2.52 g/L) | |||
Baseline | 1.9 (1.5–2.5) | 0.87 (0.4–1.6) | 0.0027 |
3 months | 1.6 (1.5–1.7) | 1.7 (1.4–2.0) | 0.23 |
Complement C4(0.12–0.75 g/L) | |||
Baseline | 0.5 (0.3–0.6) | 0.31 (0.26–0.37) | 0.96 |
3 months | 0.3 (0.3–0.5) | 0.31 (0.25–0.35) | 0.54 |
CRP (0-10 mg/dl) | |||
Baseline | 6.7 (2.4–25.9) | 4.9 (0.7–16.5) | 0.99 |
3 months | 0.3 (0–0.8) | 1.3 (0.4–4.1) | 0.99 |
ASOT (0-200 IU/ml) | |||
Baseline | 68 (19–78) | 206 (131–528) | 0.0012 |
3 months | 70 (60–118) | 163 (101–206) | 0.0143 |
IgA (0.2–3.58 g/L) | |||
Baseline | 1.3 (1.0–1.8) | 1.50 (1.3–1.7) | 0.30 |
3 months | 1.0 (0.9–1.5) | 1.46 (1.3–1.6) | 0.09 |
IgM (0.19–2.39 g/L) | |||
Baseline | 1.4 (1.3–1.7) | 1.3 (1.1–1.7) | 0.69 |
3 months | 1.1 (1.0–1.6) | 1.25 (1,0–1.6) | 0.52 |
IgG (4.5–17.1 g/L) | |||
Baseline | 5.4 (4.4–12.9) | 15.9 (12.4–19.1) | 0.007 |
3 months | 10.3 (10.1–11.7) | 16.4 (13.8–19) | 0.0006 |