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Fig. 4 | BMC Nephrology

Fig. 4

From: Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease

Fig. 4

Blockage of autophagy attenuated high Pi-induced cell atrophy in L6 cells. a Western blot shows the ratio of LC3II/I decreases with wortmannin or pLKO.1-EGFP-Atg5 (Atg5 −/−) treatment and increases with CD513B-1-Atg5 (Atg5) treatment. b Cell diameter with different treatments. Data are shown as fold change compared with the control group (3 mM, 24 h). *p < 0.05 versus control

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