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Table 2 Cases of biopsy-proven vancomycin induced AKI

From: Biopsy-proven vancomycin-induced acute kidney injury: a case report and literature review

Case

Patient Characteristics

(age/sex/infections)

Complications

Baseline

Cr (μmol/L)

Peak

Cr (μmol/L)

Biopsy

Treatment

(+ VCM withdrawal)

Final follow up

Cr (μmol/L)

â‘ 4

79/F

CNS bacteremia

 

79.6 – 97.2

1034.3

ATN+AIN

PSL

88.4

â‘¡5

67/M

S. aureus endocarditis

 

132.6 –176.8

583.4

AIN

HD

death

â‘¢6

70/M

MRSA abscess

TEN

106.1

848.6

AIN

HD+PSL

death

â‘£7

8/M

Infection of VP shunt

 

35.3

176.8

ATN

HD

35.4

⑤8

63/M

Sternal wound dehiscence

CAD

53.0 – 132.6

839.8

AIN

HD+PSL

106.1

â‘¥9

44/M

Osteomyelitis

DM

ND

751.4

AIN

HD+PSL

247.5

⑦10

51/M

Osteomyelitis

 

79.6

503.9

AIN

PSL

114.9

⑧11

45/F

Osteomyelitis

Type 2 DM

106.1

203.3

AIN

DMN

PSL

168.0

⑨11

61/M

Surgical infection

Spinal stenosis

88.4

627.6

AIN

IgAN

PSL

212.2

â‘©23

35/M

S. aureus loculated pleural effusion

 

ND

574.6

AIN

ND

114.9

⑪24

71/F

MRSA bacteremia

 

70.6

397.8

ATN

HD

HD

â‘«25

13/M

Toxic skin syndrome

SLE

106.1

495.0

ATN

LN type V

PSL

(for LN)

79.6

This case

41/M

Fornier disease

Type1 DM

79.6

1020.1

ATN+AIN

DMN

HD

109.6

  1. M male, F female, VP ventriculoperitoneal, MRSA methicillin - resistant Staphylococcus aureus, CNS coagulase negative Staphylococcus aureus, DM diabetes, SLE systemic lupus erythematosus, TEN toxic epidermal necrolysis, CAD coronary artery disease, ND not described, Cr creatinine, LN lupus nephritis, AIN acute interstitial nephritis, ATN acute tubular necrosis, HD hemodialysis, VCM vancomycin, PSL prednisolone