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Table 1 Renal Functional parameters and macrophage infiltration in C57BL/6 control and mice following the induction of NTN. Groups were compared by Mann–Whitney U test. Data are means ± SEM

From: RIPK3-deficient mice were not protected from nephrotoxic nephritis

  Control mice NTN mice
WT (n = 5) RIPK3−/−(n = 5) WT (n = 27) RIPK3−/− (n = 20)
Urinary albumin/creatinine ratio (g/mmol) 0.019 ± 0.006 0.013 ± 0.044 2.1 ± 0.51 2.0 ± 0.74
Serum urea (mmol/l) 7.7 ± 0.84 7.7 ± 0.65 11.1 ± 2.7 21.2 ± 7.2
Macrophages/gcs 1.36 ± 0.21 1.01 ± 0.15 1.9 ± 0.3 2.3 ± 0.2
  1. Abbreviations: gcs glomerular cross section, IRI ischaemia reperfusion injury, WT wild type, RIPK3 receptor interacting protein kinase 3, NTN nephrotoxic nephritis