The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study

Table 3 Multivariable linear regression analysis presenting associations between klotho and pulse wave velocity

	Variable	Model A		Model B		Model C
		β (95% CI)	P- value	β (95% CI)	P- value	β (95% CI)	P- value
baPWV	Klotho (pg/mL)	−0.011 (− 0.07, 0.04)	0.582	−0.017 (− 0.07, 0.02)	0.329	0.003 (− 0.04, 0.05)	0.876
hfPWV	Klotho (pg/mL)	−0.029 (− 0.09, 0.02)	0.228	− 0.037 (− 0.09, 0.01)	0.087	−0.013 (− 0.06, 0.034)	0.564

Model A: Adjusted for klotho, age and gender
Model B: Adjusted for klotho, age, gender, DM, HTN, BMI, and SBP
Model C: Adjusted forklotho, age, gender, DM, HTN, BMI, SBP, eGFR, hemoblogin, phosphorus, corrected Ca, and FGF23
β Standardized coefficient, CI confidence interval, baPWV brachial-to-ankle pulse wave velocity; hfPWV, heart-to-femoral pulse wave velocity; DM diabetes mellitus, HTN hypertension, BMI body mass index, SBP systolic blood pressure, eGFR estimated glomerular filtration rate by CKD-EPI creatinine equation, Ca calcium, FGF23 fibroblast growth factor 23

ISSN: 1471-2369