Fig. 5

Renal inflammation in WT (white bars) and NOD1/2 DKO (black bars) mice after 0, 3, 7, and 14 days following obstruction. KC (a) and MCP-1 (b) were measured in total kidney homogenates with specific ELISAs. Influx of granulocytes was determined by scoring Ly6+ cells (c, e). Influx of macrophages was assessed by F4/80 staining which was digitally analysed (d, f). Data are expressed as mean ± SEM. Results were analysed with the non-parametric two-tailed Mann-Whitney U-test. *P < 0.05. N = 9/group