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Table 3 Treatment parameters of SLED using citrate and systemic heparin anticoagulation

From: A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: safety, efficacy, and cost

Parameters

SLED session with Heparin n (%)

SLED session with Citrate n (%)

p

Dialysis access

976

808

0.11

 Fistula/Shunt

149 (15)

101 (13)

 

 Non-tunneled catheter

682 (70)

615 (76)

 

 Tunneled catheter

145 (15)

92 (11)

 

Dialysis filter

 Fx40

55 (6)

40 (5)

0.76

 Fx60

907 (93)

757 (94)

0.94

 Others

14 (1)

11 (1)

 

Extracorporeal circuit clotting

95 (10)

38 (5)

< 0.001

Interruption

167 (17)

84 (10)

< 0.001

 Circuit clotting

95 (57)

38 (45)

< 0.001

  Fistula/Shunt

7 (7)

3 (8)

0.76

  dialysis catheter

88 (93)

35 (92)

 

 Catheter malfunction

33 (20)

19 (23)

0.67

 Machine/shunt problems

7 (5)

3 (4)

0.76

 Bleeding

3 (2)

0

 

 Metabolic complicationsa

1 (0)

4 (5)

0.06

 Hypotension

2 (1)

3 (4)

0.23

 Death/CPR

10 (6)

7 (8)

0.95

 Diagnostic procedure or surgery

16 (10)

10 (12)

0.02

  1. 2 increased metabolic acidosis, 1 derangement of sodium, 1 uncontrollable hyperpotassemia
  2. 1 SLED session with heparin anticoagulation was broken due to uncontrollable hyperpotassemia
  3. SLED. P-value was analyzed using generalized estimating equations (GEE)
  4. CPR cardiopulmonary resuscitation: Patients received cardiopulmonary resuscitation during
  5. a 4 dialysis sessions performed with citrate were interrupted due to metabolic complication