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Table 4 Treatment parameters related to regional citrate anticoagulation. Data are present as mean ± SD

From: A novel citrate-based protocol versus heparin anticoagulation for sustained low-efficiency dialysis in the ICU: safety, efficacy, and cost

 

Basal

2h

4h

6h

8h

P

Systemic iCa++ (mmol/l)

1.13 ± 0.11

1.11 ± 0.08

1.1 ± 0.07

1.1 ± 0.07

1.11 ± 0.07

<0.001

Systemic HCO3- (mmol/l)

21.8 ± 3.9

21.7 ±.3.3

22.1 ± 3.3

22.2 ± 3.3

22.2 ± 3.4

<0.001

Systemic PH

7.34 ± 0.1

7.33 ± 0.1

7.35 ± 0.1

7.35 ± 0.1

7.35 ± 0.1

<0.001

Systemic Na+ (mmol/)

133.7 ± 5.5

133.9 ± 5.0

134 ± 4.5

134 ± 4.1

134.1 ± 4.0

<0.001

Blood flow rate (ml/min)

150 ± 15

150 ± 15

150 ± 15.8

150 ± 15.4

150 ± 12.8

0.003

Citrate infusion rate (ml/h)

59.3 ± 6.5

59.9 ± 7.2

60.2 ± 7.2

60.4 ± 7.1

60.4 ± 6.7

<0.001

Calcium infusion rate (ml/h)

9.5 ± 2.3

9.5 ± 2.7

9.3 ± 2.9

9.3 ± 3.0

9.2 ± 3.0

<0.001

Postfilter iCa++ (mmol/l)

0.47 ± 0.1

0.46 ± 0.1

0.44 ± 0.1

0.42 ± 0.1

0.41 ± 0.1

<0.001

Filter citrate removal (%)

 

66

66

70

70

 
  1. Data was analyzed using binary logistic regression. Each dot on the scatterplot represents one patient. P-value was analyzed using nested linear mixed model