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Table 3 Study outcomes

From: The effect of spironolactone on calcineurin inhibitor induced nephrotoxicity: a multicenter randomized, double-blind, clinical trial (the SPIREN trial)

Primary endpoint

Secondary endpoints

Chrome-EDTA clearance

24 h urinary protein excretion

Renal fibrosis (morphology)

Cardiovascular events

Biomarkers of fibrosis in tissue, blood and urine