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Table 1 Characteristics of patients and transplantations with late de novo DSA

From: Clinical and histological evolution after de novo donor-specific anti-human leukocyte antigen antibodies: a single centre retrospective study

 

Patients with late dnDSA (n = 22)

Recipients’ characteristics

 Age in years; mean (SD)

45 (14)

 Gender (% male)

63.6

 First transplantation (%)

100

 Living donor (% yes)

36.3

 Baseline nephropathy (%)

 

ADPKD

31.5

Glomerulopathy other than IgA nephropathy

18.3

IgA nephropathy

18.3

Diabetes mellitus and/or hypertension

13.6

Others

18.3

Transplantation characteristics

 HLA mismatches (% patients with > or = 3 mismatches)

100

 ABO incompatible (n)

1

 Delayed graft function (n, %)

8 (36.3)

 Induction therapy (n, %)

No induction

8 (36.3)

Basiliximab

8 (36.3)

ATG

5 (22.7)

Daclizumab

1 (4.5)

 Initial therapy including a triple regimena (n, %)

21 (95.4)

 Acute rejection or TCMR prior to development of dnDSA (n, %)

8 (36.3)

  1. ADPKD Autosomal dominant polycystic kidney disease, ATG Antithymoglobulin, SD Standard deviation, TCMR T-cell-mediated rejection, dnDSA de novo DSA
  2. a: defined by a combination of calcineurin inhibitor, anti-metabolite (azathioprine or mycophenolate mofetil or mycophenolic acid) and corticosteroids at one year