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Table 3 Overall clinical and histological changes over time (n = 22)

From: Clinical and histological evolution after de novo donor-specific anti-human leukocyte antigen antibodies: a single centre retrospective study

 

Biopsy at the time of dnDSA

Follow up biopsy

Paired t-test

Mean eGFR using the CKD-EPI equation (ml/min, mean +/− SD)

45.9 (16.7)

37.4 (13.8)

0.005

g (n, % of g ≥ 1)

10 (45.4)

11 (50.0)

0.47

ptc (n, % of ptc ≥ 1)

10 (45.4)

6 (27.2)

0.26

g + ptc (n, % of g + ptc ≥ 2)

10 (45.4)

7 (31.8)

0.77

Overall change in g + ptc (n, %)

Reduction in g + ptc score

 

9 (40.9)

 

No change in g + ptc score

 

7 (31.8)

 

Progression in g + ptc score

 

6 (27.3)

 

t (n, % of t ≥ 1)

4 (18.1)

0

0.04

C4d (n, % of c4d ≥ 1)

9 (40.9)

5 (22.7)

0.16

cg (n, % of cg ≥ 1)

6 (27.2)

10 (45.4)

0.04

  1. eGFR estimated glomerular filtration rate, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration, SD standard deviation, g glomerulitis, ptc peritubular capillaritis, t tubulitis, cg chronic glomerulopathy