Biomarker enhanced risk prediction for development of AKI after cardiac surgery

BMC Nephrology

Table 2 Areas under the Receiver-Operating Characteristic Curve for Acute Kidney Injury for Univariate and Multivariate Predictor

Area Under the ROC curve (95% CI)	AKI	AKI_KDIGO	P	P_KDIGO
Univariate
HRG	0.79 (0.65, 0.94)	0.79 (0.67, 0.92)	0.001	0.001
Preoperative Serum Creatinine	0.79 (0.66, 0.93)	0.63 (0.46, 0.79)	0.001	0.14
Factor B	0.75 (0.57, 0.93)	0.75 (0.60, 0.90)	0.007	0.004
Risk Factor Score	0.73 (0.56, 0.90)	0.62 (0.46, 0.79)	0.012	0.16
CD59	0.68 (0.50, 0.86)	0.67 (0.51, 0.84)	0.050	0.042
Angiotensinogen	0.65 (0.46, 0.84)	0.65 (0.48, 0.81)	0.11	0.091
C3	0.51 (0.3, 0.73)	0.59 (0.42, 0.77)	0.91	0.29
Multivariate
HRG + Preoperative Serum Creatinine	0.82 (0.68, 0.96)	0.79 (0.66, 0.92)	<0.001	0.001
Factor B + Preoperative Serum Creatinine	0.84 (0.70, 0.98)	0.74 (0.59, 0.89)	<0.001	0.005
HRG + Factor B	0.79 (0.64, 0.94)	0.79 (0.66, 0.92)	0.002	0.001
HRG + Risk Factor Score	0.90 (0.79, 1.0)	0.79 (0.66, 0.92)	<0.001	0.001

AKI_R, Restrictive AKI definition, %Correct_R, percent of patients correctly classified using restrictive classification
AKI_KDIGO, KDIGO AKI definition, %Correct_KDIGO, percent of patients correctly classified using KDIGO classification
P _R , p-value using restrictive AKI definition, P _KDIGO , p-value using KDIGO AKI definition

ISSN: 1471-2369