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Table 3 Net reclassification index* (NRI) and Integrated Discrimination Improvement (IDI) for the addition of HRG and Factor B when compared to Risk Score using the restrictive definition of AKI

From: Biomarker enhanced risk prediction for development of AKI after cardiac surgery

 

HRG

Factor B

Two-category NRI

 NRI events

33 (-13 to 69)

33 (-8.8 to 67)

 NRI nonevents

6.3 (-2.5 to 24)

9.4 (0 to 35)

 NRI

40 (-5.7 to 75)

43 (5.3 to 80)

IDI and summary statistics

 IDI events

0.23 (0.067 to 0.46)

0.24 (0.077 to 0.47)

 IDI nonevents

0.11 (0.029 to 0.23)

0.11 (0.041 to 0.23)

 IDI

0.34 (0.093 to 0.64)

0.35 (0.12 to 0.64)

 IS ref

0.38 (0.21 to 0.54)

0.38 (0.22 to 0.54)

 IS new

0.63 (0.39 to 0.82)

0.64 (0.43 to 0.81)

 IP ref

0.23 (0.13 to 0.41)

0.23 (0.13 to 0.39)

 IP new

0.15 (0.073 to 0.30)

0.15 (0.071 to 0.29)

  1. Values in parenthesis are the 95% confidence intervals; NRI and IDI were calculated for the events, non-events, and total; IS, integrated sensitivity; IP, integrated 1-specificity *[39]