Table 1 Patient demographics and clinical characteristics
Demographic | Cinacalcet withdrawal patients (n = 51) | Control patients (n = 51) | p value |
|---|---|---|---|
Age, years | 69.6 (13.2) | 68.6 (12.9) | ns |
Gender (male) | 28 (55) | 28 (55) | ns |
Dialysis modality (HD) | 44 (86) | 29 (57) | p = 0.001 |
Time on dialysis, years | 7.1 (3.6) | 6.7 (4.1) | ns |
Diabetes | 23 (45) | 23(45) | ns |
Hypertension | 39 (76) | 33 (65) | ns |
Ischemic heart disease | 23 (45) | 18 (35) | ns |
Peripheral vascular disease | 8 (15) | 15 (29) | ns |
Current or ex-smoker | 16 (31) | 17 (33) | ns |
Previous transplants | 4 (8) | 2 (4) | ns |
Parathyroidectomy | 1 (2) | 5 (10) | ns |
Previous fractures | 7 (13) | 4 (8) | ns |
Aetiology of renal disease | |||
Diabetic nephropathy | 14 (27) | 18 (35) | ns |
GN | 9 (17) | 12 (23) | ns |
PKD | 3 (6) | 4 (8) | ns |
Other | 25 | 17 | ns |
Events during follow up | |||
Cardiac arrest | 5 | 3 | ns |
Parathyroidectomy and referral for surgery | 5 | 1 | ns |
Fracture | 2 | 5 | ns |
Calciphylaxis | 1 | 0 | ns |
Deaths | 13 | 10 | ns |
Hypercalcemia at baseline | 3 | 1 | ns |
Hypercalcemia at 6 months | 9 | 0 | p = 0.007 |
Hypercalcemia at 12 months | 3 | 0 | ns |