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Table 2 Biochemical changes over 12-month period

From: Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism

Biochemistry

Cinacalcet withdrawal patients (n = 51)

Control patients (n = 51)

p value

PTH baseline, (pmol/L)

42.2 [27.8–94.6]

44 [28.5–60.9]

p = 0.98

PTH 6 months, (pmol/L)

103.9 [63.4–122.2]

41 [28.2–67.8]

p < 0.005

PTH 12 months (pmol/L)

114.8 [83.9–159.1]

41.3 [28.5–69.7]

p < 0.005

Calcium baseline (mmol/L)

2.31 (0.21)

2.32 (0.15)

p = 0.8

Calcium 6 months (mmol/L)

2.48 (0.21)

2.28 (0.18)

p < 0.005

Calcium 12 months (mmol/L)

2.46 (0.14)

2.32 (0.14)

p < 0.005

Phosphate baseline (mmol/L)

1.72 (0.55)

1.56 (0.42)

p = 0.14

Phosphate 6 months (mmol/L)

1.75 (0.47)

1.64 (0.56)

p = 0.3

Phosphate 12 months (mmol/L)

1.77 (0.58)

1.6 (0.49)

p = 0.14

ALP baseline (IU/L)

141.4 (61)

129.8 (91.8)

p = 0.45

ALP 6 months (IU/L)

155.5 (61)

126 (75.5)

p = 0.04

ALP 12 months (IU/L)

161.7 (72.9)

121.5 (45)

p = 0.003

Albumin baseline (g/L)

35 (4.2)

35.7 (4.3)

p = 0.84

Albumin 6 months (g/L)

34 (4.2)

34.9 (4.6)

p = 0.97

Albumin 12 months (g/L)

33 (4.5)

34.3 (5)

p = 0.94

CRP baseline (mg/L)

6.3 [4.6–19.6]

5 [2–16]

p = 0.312

CRP 6 months (mg/L)

7 [3.3–12.3]

4.2 [2–18]

p = 0.37

CRP 12 months (mg/L)

7.7 [3–29.5]

6.3 [2–19]

p = 0.41

Ferritin baseline (ug/L)

235.5 [102.3–322.3]

229 [140.8–399.3]

p = 0.23

Ferritin 6 months (ug/L)

209.5 [80–331.3]

232.5 [114–316]

p = 0.86

Ferritin 12 months (ug/L)

274.5 [120–383.5]

221.5 [138.5–322.8]

p = 0.64

Hemoglobin baseline (g/L)

112.7 (10.4)

110 (14)

p = 0.13

Hemoglobin 6 months (g/L)

111.6 (10.7)

107 (18)

p = 0.37

Hemoglobin 12 months (g/L)

109 (14)

114 (14)

p = 0.09

Bicarbonate baseline (mmol/L)

23 (3)

24 (3.7)

p = 0.53

Bicarbonate 6 months (mmol/L)

23.1 (3)

23.9 (3)

p = 0.9

Bicarbonate 12 months (mmol/L)

23.6 (3.2)

24 (3)

p = 0.81

25[OH]D baseline (nmol/L/L)

43[33–68]

52[42–60]

p = 0.52

25[OH]D 6 months (nmol//L)

49[32–68]

66[51–89]

p = 0.1

25[OH]D 12 months (nmol/L)

53[28–70]

60[42–97]

p = 0.36

  1. Data presented as number (percent), mean (standard deviation) or median [interquartile range]
  2. Abbreviations: ALP alkaline phosphatase, CRP C-reactive protein, PTH parathyroid hormone, 25[OH]D 25-hydroxy vitamin D