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Fig. 3 | BMC Nephrology

Fig. 3

From: IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

Fig. 3

IP3R antagonist prevented podocytes from ADR- and Ang II-induced apoptosis in vitro. Ctl, control; ADR, Adriamycin; XeC, Xestospongin C (IP3R inhibitor); a, compared with Ctl group; b, compared with the ADR or Ang II group; *, P < 0.05; **, P < 0.01. a The cells in Q3 which were annexin high and PI low were counted as apoptotic cells. Compared with ADR or Ang II -treated podocytes, XeC decreased the podocyte apoptosis rate significantly (n = 3). b Compared with ADR or Ang II -treated podocytes, XeC decreased active caspase-3 in podocytes significantly. c Compared with ADR or Ang II -treated podocytes, XeC decreased mitochondrial Ca2+ levels in podocytes significantly

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BMC Nephrology

ISSN: 1471-2369

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