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Fig. 6 | BMC Nephrology

Fig. 6

From: IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

Fig. 6

The protective effects of ruthenium red in an ADR nephropathy rat model. W, week; Ctl, normal saline group; RR, ruthenium red group; ADR, Adriamycin group; ADR + RR, Adriamycin plus RR group. a, compared with the Ctl group; b, compared with the RR group; c, compared with the ADR group. *, P < 0.05; **, P < 0.01. a Compared with the Ctl (n = 6) or RR (n = 6) groups, 24 h urinary protein levels increased significantly in the ADR group (n = 10) at 2, 4, and 6-weeks. Compared with the ADR group, 24 h urinary protein levels were decreased significantly in rats in the ADR + RR (n = 6) group at 2, 4, and 6 weeks. b and c Compared with the Ctl (n = 6) or RR (n = 6) groups, significantly increased podocyte foot process width was observed in rats in the ADR group (n = 6). Compared with the ADR group, podocyte foot process width was decreased significantly in rats in the ADR + RR group (n = 6)

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BMC Nephrology

ISSN: 1471-2369

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