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Table 2 Selected multivariable predictors of fast CKD progression over 24 months among adults with eGFR 30 to 59 ml/min/1.73 m2 stratified by baseline diabetes status

From: Contemporary rates and predictors of fast progression of chronic kidney disease in adults with and without diabetes mellitus

Characteristic Adjusteda Odds Ratio (95% Confidence Interval) for Fast Progression in Adults with Stage 3 CKD and no Diabetes
N = 23,021
Adjustedb Odds Ratio (95% Confidence Interval) for Fast Progression in Adults with Stage 3 CKD and Diabetes
N = 13,174
Age group at study entry, yr
 18–49 1.16 (0.91–1.48) 1.60 (1.22–2.10)
 50–59 0.72 (0.61–0.86) 1.16 (1.00–1.34)
 60–69 0.81 (0.73–0.90) 1.03 (0.92–1.14)
 70–79 Reference Reference
 ≥ 80 1.25 (1.14–1.36) 1.16 (1.03–1.30)
Male vs. female gender 1.00 (0.92–1.08) 0.99 (0.91–1.08)
Race
 White/European Reference Reference
 Black/African American 1.02 (0.90–1.16) 1.00 (0.88–1.14)
 Asian/Pacific Islander 1.00 (0.88–1.15) 1.02 (0.91–1.15)
 Native American 1.57 (0.81–3.04) 1.22 (0.67–2.20)
 Other 1.26 (0.68–2.34) 1.24 (0.81–1.92)
 Unknown 0.88 (0.69–1.11) 1.15 (0.94–1.42)
Hispanic ethnicity 1.05 (0.90–1.21) 1.03 (0.90–1.18)
Current/former smoking 1.21 (1.12–1.30)
Medical history
 Heart failure 1.77 (1.57–1.99) 1.58 (1.40–1.79)
 Ischemic stroke 1.50 (1.11–2.04)
 Pacemaker 1.43 (1.06–1.92)
 Proteinuria 1.86 (1.65–2.10) 2.31 (2.10–2.55)
 Valvular heart disease 0.86 (0.71–1.03)
Systolic blood pressure, mmHg
 ≤ 120 Reference Reference
 121–129 1.17 (1.04–1.30) 1.14 (1.01–1.29)
 130–139 1.28 (1.15–1.41) 1.23 (1.08–1.39)
 140–159 1.44 (1.28–1.62) 1.47 (1.29–1.68)
 160–179 2.07 (1.75–2.46) 1.99 (1.64–2.42)
 ≥ 180 2.42 (1.80–3.24) 2.21 (1.59–3.08)
 Unknown 1.12 (0.88–1.43) 1.20 (0.94–1.53)
Laboratory values
 Hemoglobin, g/dL
  ≥ 13.0 Reference Reference
  12.0–12.9 1.38 (1.25–1.53) 1.39 (1.23–1.56)
  11.0–11.9 2.02 (1.78–2.29) 1.63 (1.43–1.87)
  10.0–10.9 2.09 (1.73–2.54) 1.76 (1.47–2.11)
  9.0–9.9 1.46 (1.02–2.10) 2.09 (1.55–2.81)
  < 9.0 1.44 (0.85–2.43) 2.15 (1.26–3.68)
  Unknown 1.13 (1.01–1.26) 1.15 (1.02–1.30)
 HDL cholesterol, mg/dL
  ≥ 60 Reference
  50–59 1.09 (0.97–1.23)
  40–49 1.16 (1.04–1.30)
  35–39 1.25 (1.08–1.45)
  < 35 1.27 (1.07–1.50)
  Unknown 1.20 (1.07–1.36)
 LDL cholesterol, mg/dL
  ≥ 200 Reference
  160–199 1.73 (1.06–2.84)
  130–159 1.07 (0.80–1.44)
  100–129 1.10 (0.89–1.35)
  70–99 1.03 (0.90–1.17)
  < 70 0.93 (0.84–1.02)
  Unknown 1.07 (0.82–1.39)
  1. aAdjusted also for baseline level of eGFR and receipt of angiotensin II receptor blockers and calcium channel blockers at entry
  2. bAdjusted also for baseline level of eGFR and receipt of diuretics, calcium channel blockers and hydralazine at entry