Characteristic | Adjusteda Odds Ratio (95% Confidence Interval) for Fast Progression in Adults with Stage 3 CKD and no Diabetes N = 23,021 | Adjustedb Odds Ratio (95% Confidence Interval) for Fast Progression in Adults with Stage 3 CKD and Diabetes N = 13,174 |
---|---|---|
Age group at study entry, yr | ||
 18–49 | 1.16 (0.91–1.48) | 1.60 (1.22–2.10) |
 50–59 | 0.72 (0.61–0.86) | 1.16 (1.00–1.34) |
 60–69 | 0.81 (0.73–0.90) | 1.03 (0.92–1.14) |
 70–79 | Reference | Reference |
 ≥ 80 | 1.25 (1.14–1.36) | 1.16 (1.03–1.30) |
Male vs. female gender | 1.00 (0.92–1.08) | 0.99 (0.91–1.08) |
Race | ||
 White/European | Reference | Reference |
 Black/African American | 1.02 (0.90–1.16) | 1.00 (0.88–1.14) |
 Asian/Pacific Islander | 1.00 (0.88–1.15) | 1.02 (0.91–1.15) |
 Native American | 1.57 (0.81–3.04) | 1.22 (0.67–2.20) |
 Other | 1.26 (0.68–2.34) | 1.24 (0.81–1.92) |
 Unknown | 0.88 (0.69–1.11) | 1.15 (0.94–1.42) |
Hispanic ethnicity | 1.05 (0.90–1.21) | 1.03 (0.90–1.18) |
Current/former smoking | 1.21 (1.12–1.30) | – |
Medical history | ||
 Heart failure | 1.77 (1.57–1.99) | 1.58 (1.40–1.79) |
 Ischemic stroke | 1.50 (1.11–2.04) | – |
 Pacemaker | 1.43 (1.06–1.92) | – |
 Proteinuria | 1.86 (1.65–2.10) | 2.31 (2.10–2.55) |
 Valvular heart disease | – | 0.86 (0.71–1.03) |
Systolic blood pressure, mmHg | ||
 ≤ 120 | Reference | Reference |
 121–129 | 1.17 (1.04–1.30) | 1.14 (1.01–1.29) |
 130–139 | 1.28 (1.15–1.41) | 1.23 (1.08–1.39) |
 140–159 | 1.44 (1.28–1.62) | 1.47 (1.29–1.68) |
 160–179 | 2.07 (1.75–2.46) | 1.99 (1.64–2.42) |
 ≥ 180 | 2.42 (1.80–3.24) | 2.21 (1.59–3.08) |
 Unknown | 1.12 (0.88–1.43) | 1.20 (0.94–1.53) |
Laboratory values | ||
 Hemoglobin, g/dL | ||
  ≥ 13.0 | Reference | Reference |
  12.0–12.9 | 1.38 (1.25–1.53) | 1.39 (1.23–1.56) |
  11.0–11.9 | 2.02 (1.78–2.29) | 1.63 (1.43–1.87) |
  10.0–10.9 | 2.09 (1.73–2.54) | 1.76 (1.47–2.11) |
  9.0–9.9 | 1.46 (1.02–2.10) | 2.09 (1.55–2.81) |
  < 9.0 | 1.44 (0.85–2.43) | 2.15 (1.26–3.68) |
  Unknown | 1.13 (1.01–1.26) | 1.15 (1.02–1.30) |
 HDL cholesterol, mg/dL | ||
  ≥ 60 | Reference | – |
  50–59 | 1.09 (0.97–1.23) | – |
  40–49 | 1.16 (1.04–1.30) | – |
  35–39 | 1.25 (1.08–1.45) | – |
  < 35 | 1.27 (1.07–1.50) | – |
  Unknown | 1.20 (1.07–1.36) | – |
 LDL cholesterol, mg/dL | ||
  ≥ 200 | – | Reference |
  160–199 | – | 1.73 (1.06–2.84) |
  130–159 | – | 1.07 (0.80–1.44) |
  100–129 | – | 1.10 (0.89–1.35) |
  70–99 | – | 1.03 (0.90–1.17) |
  < 70 | – | 0.93 (0.84–1.02) |
  Unknown | – | 1.07 (0.82–1.39) |