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Table 1 Pathway enrichment analysis of the down-regulated differentially expressed genes in monocytes of IgAN patients

From: Gene alterations in monocytes are pathogenic factors for immunoglobulin a nephropathy by bioinformatics analysis of microarray data

Term Count Genes P value
hsa05322:Systemic lupus erythematosus 9 C1QA, HLA-DQB1, HIST1H2AC, TNF, HIST2H2BE, HIST1H2BH, H2AFY2, HIST3H2A, HLA-DQA2 3.52 × 10−5
hsa05332:Graft-versus-host disease 6 HLA-DQB1, IL6, TNF, IL1B, HLA-DQA2, IL1A 1.29 × 10−4
hsa04640:Hematopoietic cell lineage 7 CD55, IL6, TNF, IL1B, ITGB3, ITGA4, IL1A 7.92 × 10−4
hsa04940:Type I diabetes mellitus 5 HLA-DQB1, TNF, IL1B, HLA-DQA2, IL1A 2.00 × 10−3
hsa04621:NOD-like receptor signaling pathway 5 IL6, TNF, CXCL2, IL1B, TNFAIP3 8.22 × 10−3
hsa05020:Prion diseases 4 C1QA, IL6, IL1B, IL1A 1.02 × 10− 2
hsa04060:Cytokine-cytokine receptor interaction 9 IL6, TNF, CCL20, CXCL3, CXCL2, CSF2RB, IL1B, IL1A, TNFSF8 1.91 × 10−2
hsa04672:Intestinal immune network for IgA production 4 HLA-DQB1, IL6, ITGA4, HLA-DQA2 2.52 × 10−2
hsa04210:Apoptosis 5 TNF, CYCS, CSF2RB, IL1B, IL1A 2.58 × 10−2