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Table 1 Pathway enrichment analysis of the down-regulated differentially expressed genes in monocytes of IgAN patients
| Term | Count | Genes | P value |
|---|---|---|---|
| hsa05322:Systemic lupus erythematosus | 9 | C1QA, HLA-DQB1, HIST1H2AC, TNF, HIST2H2BE, HIST1H2BH, H2AFY2, HIST3H2A, HLA-DQA2 | 3.52 × 10−5 |
| hsa05332:Graft-versus-host disease | 6 | HLA-DQB1, IL6, TNF, IL1B, HLA-DQA2, IL1A | 1.29 × 10−4 |
| hsa04640:Hematopoietic cell lineage | 7 | CD55, IL6, TNF, IL1B, ITGB3, ITGA4, IL1A | 7.92 × 10−4 |
| hsa04940:Type I diabetes mellitus | 5 | HLA-DQB1, TNF, IL1B, HLA-DQA2, IL1A | 2.00 × 10−3 |
| hsa04621:NOD-like receptor signaling pathway | 5 | IL6, TNF, CXCL2, IL1B, TNFAIP3 | 8.22 × 10−3 |
| hsa05020:Prion diseases | 4 | C1QA, IL6, IL1B, IL1A | 1.02 × 10− 2 |
| hsa04060:Cytokine-cytokine receptor interaction | 9 | IL6, TNF, CCL20, CXCL3, CXCL2, CSF2RB, IL1B, IL1A, TNFSF8 | 1.91 × 10−2 |
| hsa04672:Intestinal immune network for IgA production | 4 | HLA-DQB1, IL6, ITGA4, HLA-DQA2 | 2.52 × 10−2 |
| hsa04210:Apoptosis | 5 | TNF, CYCS, CSF2RB, IL1B, IL1A | 2.58 × 10−2 |
