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Table 2 Enrichment analysis of hub genes in the protein-protein interaction network
| Term | Genes | P value |
|---|---|---|
| hsa05020:Prion diseases | IL6, IL1B, PRKACA, HSPA1B, IL1A | 1.30 × 10−4 |
| hsa04630:Jak-STAT signaling pathway | TYK2, STAT4, IL6, SOCS2, PIAS3, CSF2RB, CISH | 1.03 × 10−3 |
| hsa04621:NOD-like receptor signaling pathway | IL6, TNF, CXCL2, IL1B, TNFAIP3 | 1.20 × 10−3 |
| hsa05332:Graft-versus-host disease | IL6, TNF, IL1B, IL1A | 3.15 × 10−3 |
| hsa04060:Cytokine-cytokine receptor interaction | IL6, TNF, CCL20, CXCL3, CXCL2, CSF2RB, IL1B, IL1A | 3.31 × 10−3 |
| hsa04640:Hematopoietic cell lineage | IL6, TNF, IL1B, ITGA4, IL1A | 4.00 × 10−3 |
| hsa04210:Apoptosis | TNF, CSF2RB, IL1B, PRKACA, IL1A | 4.17 × 10−3 |
| hsa04620:Toll-like receptor signaling pathway | IL6, TNF, IL1B, TLR6, TRAF3 | 7.08 × 10−3 |
| hsa04940:Type I diabetes mellitus | TNF, IL1B, IL1A | 4.07 × 10−2 |
