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Table 2 Enrichment analysis of hub genes in the protein-protein interaction network

From: Gene alterations in monocytes are pathogenic factors for immunoglobulin a nephropathy by bioinformatics analysis of microarray data

Term Genes P value
hsa05020:Prion diseases IL6, IL1B, PRKACA, HSPA1B, IL1A 1.30 × 10−4
hsa04630:Jak-STAT signaling pathway TYK2, STAT4, IL6, SOCS2, PIAS3, CSF2RB, CISH 1.03 × 10−3
hsa04621:NOD-like receptor signaling pathway IL6, TNF, CXCL2, IL1B, TNFAIP3 1.20 × 10−3
hsa05332:Graft-versus-host disease IL6, TNF, IL1B, IL1A 3.15 × 10−3
hsa04060:Cytokine-cytokine receptor interaction IL6, TNF, CCL20, CXCL3, CXCL2, CSF2RB, IL1B, IL1A 3.31 × 10−3
hsa04640:Hematopoietic cell lineage IL6, TNF, IL1B, ITGA4, IL1A 4.00 × 10−3
hsa04210:Apoptosis TNF, CSF2RB, IL1B, PRKACA, IL1A 4.17 × 10−3
hsa04620:Toll-like receptor signaling pathway IL6, TNF, IL1B, TLR6, TRAF3 7.08 × 10−3
hsa04940:Type I diabetes mellitus TNF, IL1B, IL1A 4.07 × 10−2