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Table 1 Demographic and clinical characteristics of participants according to the presence or absence of hematuria at baseline

From: Hematuria as a risk factor for progression of chronic kidney disease and death: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study

  Dipstick Positive 1145 (35) Dipstick Negative 2127 (65) Total 3272 (100)
Demography
 Age (years; mean +/− SD) 55 +/− 12 59+/− 10 57+/− 11
 Female Sex (n [%]) 470 (41) 935 (44) 1405 (43)
Racial/ethnic group (n [%])
  Non-Hispanic White 365 (32) 940 (44) 1305 (40)
  Non-Hispanic Black/African American 489 (43) 930 (44) 1419 (43)
  Hispanic 254 (22) 204 (10) 458 (14)
  Other 37 (3) 53 (2) 90 (3)
ApoL1 recessive genetic model (n [%])a
  0 or 1 copy of APOL1 risk variants 350 (81) 665 (79) 1015 (80)
  2 copies of APOL1 risk variants 80 (19) 176 (21) 256 (20)
Educational attainment (n [%])
  Less than high school 346 (30) 430 (20) 776 (24)
  High school graduate 239 (21) 426 (20) 665 (20)
  Some college 319 (28) 607 (29) 926 (28)
  College graduate or higher 241 (21) 664 (31) 905 (28)
Anthropometry
 BMI (kg/m2; mean +/-SD) 32+/−8 32+/− 8 32+/− 8
BMI (kg/m2; n [%])    
   < 25 207 (18) 282 (13) 489 (15)
  25 to < 30 302 (26) 625 (29) 927 (28)
   > =30 633 (55) 1215 (57) 1848 (57)
 Abdominal Circumference (cm; mean +/-SD) 105+/− 18 106+/− 17 106+/− 18
 Fat free mass [kg; median (IQR)] 61 (50 to 72) 59 (49 to 70) 60 (50 to 71)
 Ankle-brachial index< 0.9 (n [%]) 209 (19) 326 (16) 535 (17)
 Systolic Blood P. (mmHg; mean +/-SD) 134+/− 24 127/− 21 129+/− 22
 Diabetes 638 (56) 1014 (48) 1652 (50)
 Hypertension 1013 (88) 1878 (88) 2891 (88)
Tobacco use (n [%])
  Current smoker 189 (17) 273 (13) 462 (14)
  More than 100 cigarettes during lifetime 638 (56) 1180 (55) 1818 (56)
Cancer (n[%])
  Any cancer in the last 5 years 68 (6) 158 (7) 226 (7)
  Any non-skin cancer in the last 5 years 56 (5) 107 (5) 163 (5)
Cardiovascular Disease (n [%])
  Congestive Heart Failure 111 (10) 229 (11) 340 (10)
  Peripheral Vascular Disease 103 (9) 137 (6) 240 (7)
  Coronary Disease 232 (20) 514 (24) 746 (23)
  Cerebrovascular Disesase 124 (11) 215 (10) 339 (10)
  Any Cardiovascular Disease 385 (34) 753 (35) 1138 (35)
Renal Function
 eGFR (ml/min/1.73 m2; mean +/-SD) 40+/−15 45+/−16 44+/− 16
eGFR (ml/min/1.73 m2; n[%]) (CRIC Eq.)
  < 30 329 (29) 390 (18) 719 (22)
  30 to < 40 289 (25) 507 (24) 796 (24)
  40 to < 50 239 (21) 480 (23) 719 (22)
  50 to < 60 167 (15) 380 (18) 547 (17)
  > = 60 121 (11) 370 (17) 491 (15)
Urinalysis
 24H Urine Albumin [g; median (IQR)] 0.50 (0.05 to 1.76) 0.04 (0.0 to 0.26) 0.08 (0.01 to 0.61)
24H Urine Albumin (n[%])    
  < 30 mg/day 211 (19.54) 951 (46.66) 1162 (37.27)
  30 to < 300 mg/day 260 (24.07) 605 (29.69) 865 (27.74)
  300 to < 1000 mg/day 224 (20.74) 286 (14.03) 510 (16.36)
  > = 1000 mg/day 385 (35.65) 196 (9.62) 581 (18.63)
Other laboratory markers
 Hemoglobin (g/dl; mean+/-SD) 12.3+/−1.9 12.6+/−1.7 12.5+/− 1.8
 CalciumT (mg/dl; mean +/-SD) 9.2+/−0.5 9.2+/−0.5 9.2+/−0.5
 Phosphate (mg/dl; mean +/-SD) 3.9+/− 0.7 3.7+/− 0.6 3.7+/− 0.7
 iPTH [pg/ml; median (IQR)] 63 (38 to 107) 52 (34 to 85) 56 (36 to 92)
 FGF23 [RU/ml; median (IQR)] 175 (105 to 284) 141 (95 to 224) 150 (99 to 249)
 Vitamin D [ng/ml; median (IQR)] 17.6 (10.8 to 27.2) 22.9 (14.5 to 34) 20.8 (12.8 to 31.7)
 Glucose [mg/dl; median (IQR)] 100 (87 to 133) 98 (87 to 123) 98 (87 to 127)
 HbA1C [%; median (IQR)] 6.4 (5.6 to 7.9) 6.1 (5.6 to 7.2) 6.2 (5.6 to 7.4)
 HOMAb[mmol/L*μU/mL; median (IQR)] 4.5 (2.7 to 8.0) 4.1 (2.5 to 7.2) 4.2 (2.6 to 7.5)
 Total Cholesterol (mg/dl; mean+/-SD) 191+/−53 179+/−42 183/−46
 HDL (mg/dl; mean+/-SD) 46+/−15 47+/−15 47+/−15
 LDL (mg/dl; mean+/-SD) 107+/−39 100+/−34 102+/−36
 Triglycerides [mg/dl; median (IQR)] 138 (94 to 198) 127 (88 to 183) 130 (91 to 189)
 Albumin [g/dl; median (IQR)] 3.8 (3.4 to 4.1) 4.0 (3.7 to 4.3) 3.9 (3.6 to 4.2)
 Uric Acid (mg/dl; mean+/-SD) 7.5+/−1.9 7.5+/−1.9 7.5+/−1.9
 High sensitivity CRP [mg/l; median (IQR)] 2.8 (1.1 to 6.7) 2.6 (1.1 to 6.6) 2.6 (1.1 to 6.6)
 High sens.Troponin T [pg/mL; median (IQR)] 15.7 (7.3 to 34.3) 11.9 (6.0 to 21.6) 12.9 (6.3 to 24.6)
 NTproBNP [pg/mL; median (IQR)] 204 (81 to 588) 142 (58 to 370) 162 (66 to 439)
Medication (n [%])
 ACE/ARB 786 (69.3) 1492 (70.7) 2278 (70.2)
 Any anti-platelet agent 458 (40.4) 1038 (49.2) 1496 (46.1)
 cAMP and Ca modifiers 83 (7.3) 173 (8.2) 256 (7.9)
 Cox-1-inhibitor 425 (37.5) 968 (45.9) 1393 (42.9)
 Eicosapentaenoic acid 0 (0) 2 (0.09) 2 (0.06)
 Heparin 3 (0.26) 0 (0) 3 (0.09)
 Vitamin K antagonist 84 (7) 113 (5) 197 (6)
  1. aApol1 recessive genetic model described among a sample of 1271 non-Hispanic black participants. bHOMA: Insulin Resistance Index