|
Demography
|
|
Age (years; mean +/− SD)
|
55 +/− 12
|
59+/− 10
|
57+/− 11
|
|
Female Sex (n [%])
|
470 (41)
|
935 (44)
|
1405 (43)
|
|
Racial/ethnic group (n [%])
|
|
Non-Hispanic White
|
365 (32)
|
940 (44)
|
1305 (40)
|
|
Non-Hispanic Black/African American
|
489 (43)
|
930 (44)
|
1419 (43)
|
|
Hispanic
|
254 (22)
|
204 (10)
|
458 (14)
|
|
Other
|
37 (3)
|
53 (2)
|
90 (3)
|
|
ApoL1 recessive genetic model (n [%])a
|
|
0 or 1 copy of APOL1 risk variants
|
350 (81)
|
665 (79)
|
1015 (80)
|
|
2 copies of APOL1 risk variants
|
80 (19)
|
176 (21)
|
256 (20)
|
|
Educational attainment (n [%])
|
|
Less than high school
|
346 (30)
|
430 (20)
|
776 (24)
|
|
High school graduate
|
239 (21)
|
426 (20)
|
665 (20)
|
|
Some college
|
319 (28)
|
607 (29)
|
926 (28)
|
|
College graduate or higher
|
241 (21)
|
664 (31)
|
905 (28)
|
|
Anthropometry
|
|
BMI (kg/m2; mean +/-SD)
|
32+/−8
|
32+/− 8
|
32+/− 8
|
|
BMI (kg/m2; n [%])
| | | |
|
< 25
|
207 (18)
|
282 (13)
|
489 (15)
|
|
25 to < 30
|
302 (26)
|
625 (29)
|
927 (28)
|
|
> =30
|
633 (55)
|
1215 (57)
|
1848 (57)
|
|
Abdominal Circumference (cm; mean +/-SD)
|
105+/− 18
|
106+/− 17
|
106+/− 18
|
|
Fat free mass [kg; median (IQR)]
|
61 (50 to 72)
|
59 (49 to 70)
|
60 (50 to 71)
|
|
Ankle-brachial index< 0.9 (n [%])
|
209 (19)
|
326 (16)
|
535 (17)
|
|
Systolic Blood P. (mmHg; mean +/-SD)
|
134+/− 24
|
127/− 21
|
129+/− 22
|
|
Diabetes
|
638 (56)
|
1014 (48)
|
1652 (50)
|
|
Hypertension
|
1013 (88)
|
1878 (88)
|
2891 (88)
|
|
Tobacco use (n [%])
|
|
Current smoker
|
189 (17)
|
273 (13)
|
462 (14)
|
|
More than 100 cigarettes during lifetime
|
638 (56)
|
1180 (55)
|
1818 (56)
|
|
Cancer (n[%])
|
|
Any cancer in the last 5 years
|
68 (6)
|
158 (7)
|
226 (7)
|
|
Any non-skin cancer in the last 5 years
|
56 (5)
|
107 (5)
|
163 (5)
|
|
Cardiovascular Disease (n [%])
|
|
Congestive Heart Failure
|
111 (10)
|
229 (11)
|
340 (10)
|
|
Peripheral Vascular Disease
|
103 (9)
|
137 (6)
|
240 (7)
|
|
Coronary Disease
|
232 (20)
|
514 (24)
|
746 (23)
|
|
Cerebrovascular Disesase
|
124 (11)
|
215 (10)
|
339 (10)
|
|
Any Cardiovascular Disease
|
385 (34)
|
753 (35)
|
1138 (35)
|
|
Renal Function
|
|
eGFR (ml/min/1.73 m2; mean +/-SD)
|
40+/−15
|
45+/−16
|
44+/− 16
|
|
eGFR (ml/min/1.73 m2; n[%]) (CRIC Eq.)
|
|
< 30
|
329 (29)
|
390 (18)
|
719 (22)
|
|
30 to < 40
|
289 (25)
|
507 (24)
|
796 (24)
|
|
40 to < 50
|
239 (21)
|
480 (23)
|
719 (22)
|
|
50 to < 60
|
167 (15)
|
380 (18)
|
547 (17)
|
|
> = 60
|
121 (11)
|
370 (17)
|
491 (15)
|
|
Urinalysis
|
|
24H Urine Albumin [g; median (IQR)]
|
0.50 (0.05 to 1.76)
|
0.04 (0.0 to 0.26)
|
0.08 (0.01 to 0.61)
|
|
24H Urine Albumin (n[%])
| | | |
|
< 30 mg/day
|
211 (19.54)
|
951 (46.66)
|
1162 (37.27)
|
|
30 to < 300 mg/day
|
260 (24.07)
|
605 (29.69)
|
865 (27.74)
|
|
300 to < 1000 mg/day
|
224 (20.74)
|
286 (14.03)
|
510 (16.36)
|
|
> = 1000 mg/day
|
385 (35.65)
|
196 (9.62)
|
581 (18.63)
|
|
Other laboratory markers
|
|
Hemoglobin (g/dl; mean+/-SD)
|
12.3+/−1.9
|
12.6+/−1.7
|
12.5+/− 1.8
|
|
CalciumT (mg/dl; mean +/-SD)
|
9.2+/−0.5
|
9.2+/−0.5
|
9.2+/−0.5
|
|
Phosphate (mg/dl; mean +/-SD)
|
3.9+/− 0.7
|
3.7+/− 0.6
|
3.7+/− 0.7
|
|
iPTH [pg/ml; median (IQR)]
|
63 (38 to 107)
|
52 (34 to 85)
|
56 (36 to 92)
|
|
FGF23 [RU/ml; median (IQR)]
|
175 (105 to 284)
|
141 (95 to 224)
|
150 (99 to 249)
|
|
Vitamin D [ng/ml; median (IQR)]
|
17.6 (10.8 to 27.2)
|
22.9 (14.5 to 34)
|
20.8 (12.8 to 31.7)
|
|
Glucose [mg/dl; median (IQR)]
|
100 (87 to 133)
|
98 (87 to 123)
|
98 (87 to 127)
|
|
HbA1C [%; median (IQR)]
|
6.4 (5.6 to 7.9)
|
6.1 (5.6 to 7.2)
|
6.2 (5.6 to 7.4)
|
|
HOMAb[mmol/L*μU/mL; median (IQR)]
|
4.5 (2.7 to 8.0)
|
4.1 (2.5 to 7.2)
|
4.2 (2.6 to 7.5)
|
|
Total Cholesterol (mg/dl; mean+/-SD)
|
191+/−53
|
179+/−42
|
183/−46
|
|
HDL (mg/dl; mean+/-SD)
|
46+/−15
|
47+/−15
|
47+/−15
|
|
LDL (mg/dl; mean+/-SD)
|
107+/−39
|
100+/−34
|
102+/−36
|
|
Triglycerides [mg/dl; median (IQR)]
|
138 (94 to 198)
|
127 (88 to 183)
|
130 (91 to 189)
|
|
Albumin [g/dl; median (IQR)]
|
3.8 (3.4 to 4.1)
|
4.0 (3.7 to 4.3)
|
3.9 (3.6 to 4.2)
|
|
Uric Acid (mg/dl; mean+/-SD)
|
7.5+/−1.9
|
7.5+/−1.9
|
7.5+/−1.9
|
|
High sensitivity CRP [mg/l; median (IQR)]
|
2.8 (1.1 to 6.7)
|
2.6 (1.1 to 6.6)
|
2.6 (1.1 to 6.6)
|
|
High sens.Troponin T [pg/mL; median (IQR)]
|
15.7 (7.3 to 34.3)
|
11.9 (6.0 to 21.6)
|
12.9 (6.3 to 24.6)
|
|
NTproBNP [pg/mL; median (IQR)]
|
204 (81 to 588)
|
142 (58 to 370)
|
162 (66 to 439)
|
|
Medication (n [%])
|
|
ACE/ARB
|
786 (69.3)
|
1492 (70.7)
|
2278 (70.2)
|
|
Any anti-platelet agent
|
458 (40.4)
|
1038 (49.2)
|
1496 (46.1)
|
|
cAMP and Ca modifiers
|
83 (7.3)
|
173 (8.2)
|
256 (7.9)
|
|
Cox-1-inhibitor
|
425 (37.5)
|
968 (45.9)
|
1393 (42.9)
|
|
Eicosapentaenoic acid
|
0 (0)
|
2 (0.09)
|
2 (0.06)
|
|
Heparin
|
3 (0.26)
|
0 (0)
|
3 (0.09)
|
|
Vitamin K antagonist
|
84 (7)
|
113 (5)
|
197 (6)
|
