| |
MODEL 1
|
MODEL 2
|
MODEL 3
|
|---|
|
HR (95% CI)
|
p-value
|
HR (95% CI)
|
p-value
|
HR (95% CI)
|
p-value
|
|---|
|
Halving of eGFR/ESRD
| | |
|
year 1
|
4.77 (3.15 to 7.25)
|
< 0.001
|
1.89 (1.24 to 2.87)
|
0.003
|
1.74 (1.14 to 2.65)
|
0.01
|
|
year 2
|
3.13 (2.37 to 4.13)
|
< 0.001
|
1.45 (1.09 to 1.92)
|
0.01
|
1.38 (1.04 to 1.83)
|
0.03
|
|
year 3
|
1.74 (1.29 to 2.34)
|
< 0.001
|
0.86 (0.63 to 1.16)
|
0.32
|
0.82 (0.60 to 1.11)
|
0.2
|
|
year 4
|
2.01 (1.46 to 2.77)
|
< 0.001
|
1.01 (0.73 to 1.41)
|
0.94
|
0.99 (0.71 to 1.38)
|
0.94
|
|
year 5
|
2.35 (1.65 to 3.36)
|
< 0.001
|
1.25 (0.87 to 1.79)
|
0.24
|
1.22 (0.85 to 1.75)
|
0.29
|
|
after year 5
|
1.74 (1.35 to 2.25)
|
< 0.001
|
1.07 (0.82 to 1.39)
|
0.63
|
1.05 (0.81 to 1.37)
|
0.7
|
|
ESRD
| | |
|
year 1
|
6.79 (3.75 to 12.28)
|
< 0.001
|
2.40 (1.32 to 4.35)
|
0.004
|
2.22 (1.22 to 4.04)
|
0.009
|
|
year 2
|
3.85 (2.70 to 5.50)
|
< 0.001
|
1.67 (1.16 to 2.39)
|
0.005
|
1.57 (1.09 to 2.26)
|
0.014
|
|
year 3
|
1.61 (1.12 to 2.31)
|
0.01
|
0.76 (0.52 to 1.09)
|
0.13
|
0.73 (0.51 to 1.06)
|
0.1
|
|
year 4
|
1.62 (1.15 to 2.29)
|
0.006
|
0.77 (0.54 to 1.10)
|
0.15
|
0.75 (0.53 to 1.07)
|
0.12
|
|
year 5
|
2.50 (1.73 to 3.63)
|
< 0.001
|
1.19 (0.81 to 1.74)
|
0.37
|
1.19 (0.81 to 1.74)
|
0.38
|
|
after year 5
|
1.76 (1.35 to 2.29)
|
< 0.001
|
1.04 (0.79 to 1.36)
|
0.77
|
1.06 (0.81 to 1.40)
|
0.67
|
|
Death
| | |
|
year 1
|
2.33 (1.36 to 3.97)
|
0.002
|
2.02 (1.18 to 3.46)
|
0.011
|
1.88 (1.10 to 3.23)
|
0.021
|
|
year 2
|
2.07 (1.23 to 3.47)
|
0.006
|
1.88 (1.11 to 3.16)
|
0.018
|
1.75 (1.04 to 2.95)
|
0.035
|
|
year 3
|
1.14 (0.65 to 2.02)
|
0.65
|
1.07 (0.61 to 1.89)
|
0.81
|
1.02 (0.58 to 1.80)
|
0.95
|
|
year 4
|
0.70 (0.38 to 1.28)
|
0.25
|
0.66 (0.36 to 1.21)
|
0.18
|
0.61 (0.33 to 1.11)
|
0.11
|
|
year 5
|
1.35 (0.83 to 2.20)
|
0.23
|
1.33 (0.81 to 2.17)
|
0.26
|
1.19 (0.73 to 1.94)
|
0.49
|
|
after year 5
|
1.04 (0.74 to 1.46)
|
0.84
|
1.12 (0.79 to 1.58)
|
0.52
|
1.01 (0.71 to 1.42)
|
0.97
|
- Halving of eGFR/ESRD: MODEL 1:unadjusted (p-value for the interaction with time:< 0.001); MODEL 2: adjusted for age, race, sex, education, diabetes, eGFR, albuminuria, systolic blood pressure (p-value for the interaction with time: 0.025); MODEL 3: adjusted for variables from MODEL 2 and BMI, NT-pro-BNP, HbA1c, FGF23, serum albumin (p-value for the interaction with time: 0.0426);
- ESRD: MODEL 1: unadjusted (p-value for the interaction with time: < 0.001); MODEL 2: adjusted for age, race, sex, education, diabetes, eGFR, albuminuria, systolic blood pressure (p-value for the interaction with time: 0.001); MODEL 3: adjusted for variables from MODEL 2 and BMI, NT-pro-BNP, FGF23, serum albumin, high-sensitivity CRP (p-value for the interaction with time: 0.0022);
- DEATH: MODEL 1: unadjusted (p-value for the interaction with time: 0.019); MODEL 2: adjusted for age, race, sex, education, diabetes, eGFR, albuminuria, systolic blood pressure, abi, smoking, cvd (p-value for the interaction with time: 0.0614); MODEL 3: adjusted for variables from MODEL 2 and NT-pro-BNP, High sensitive troponin T, Calcium, FGF23, high-sensitivity CRP (p-value for the interaction with time: 0.0517)
