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Table 1 Body weight, plasma markers and kidney function

From: Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15

  Control Subtotal nephrectomy (STNx)
Vehicle Vehicle Ramipril
n 9 10 10
Body weight (g) 232 ± 3.6 223 ± 1.6* 241 ± 4.2††
Left kidney weight (g) 0.75 ± 0.09 1.15 ± 0.07*** 1.01 ± 0.51†††
Left kidney /body weight (g/100 g) 0.24 ± 0.01 0.35 ± 0.01*** 0.24 ± 0.003†††
Plasma ACE activity (nmol/ml/hr) 1474 ± 156 1624 ± 101 13 ± 4†††
Plasma urea (mmol/l) 5.3 ± 0.2 9.5 ± 0.6*** 10.8 ± 0.7
Urine protein (mg/100 g/24 h) 57.2 ± 2.5 91.7 ± 10.7** 66.6 ± 3.2
Plasma creatinine (μmol/l) 22 ± 1 45 ± 4*** 46 ± 2
Creatinine clearance (ml/min) 2.84 ± 0.20 1.39 ± 0.17*** 1.49 ± 0.10
  1. Data are presented as mean ± SEM. Control vs. STNx-vehicle (disease effect) *P < 0.05, **P < 0.01, ***P < 0.001; STNx-vehicle vs. ramipril (treatment effect) P < 0.05, ††P < 0.01, †††P < 0.001
  2. Abbreviations: ACE Angiotensin converting enzyme