Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15

Table 2 Blood pressure and cardiac function and fibrosis

	Control	Subtotal nephrectomy (STNx)
	Vehicle	Vehicle	Ramipril
n	9	10	10
Blood pressure and cardiac function
Heart rate (beats/min)	354 ± 10	377 ± 17	380 ± 12
Systolic blood pressure (mmHg)	139 ± 4	205 ± 18**	119 ± 6^†††
Diastolic blood pressure (mmHg)	108 ± 3	138 ± 11**	90 ± 6^††
Mean arterial pressure (mmHg)	125 ± 4	189 ± 6***	106 ± 6^†††
dP/dt_max (mmHg/s)	10,870 ± 776	14,739 ± 1468*	11,342 ± 924
dP/dt_min (mmHg/s)	−10,593 ± 710	−10,570 ± 1509	−10,556 ± 836
Tau (ms)	14 ± 1	18 ± 1*	13 ± 1^††
LVEDP (mmHg)	10.8 ± 0.9	17.1 ± 1.8**	11.4 ± 0.7^†
Cardiac fibrosis
Interstitial (%)	2.5 ± 0.33	8.9 ± 1.8*	3.6 ± 0.2^†
Perivascular (%)	23 ± 2	27 ± 2	28 ± 2

Data are presented as mean ± SEM. Control vs. STNx-vehicle (disease effect) *P < 0.05, **P < 0.01, ***P <0.001; STNx-vehicle vs. ramipril (treatment effect) ^†P < 0.05, ^††P < 0.01, ^†††P < 0.001
Abbreviations: LVDEP left ventricular end diastolic pressure

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