Skip to main content

Advertisement

Table 2 Blood pressure and cardiac function and fibrosis

From: Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15

  Control Subtotal nephrectomy (STNx)
Vehicle Vehicle Ramipril
n 9 10 10
Blood pressure and cardiac function
 Heart rate (beats/min) 354 ± 10 377 ± 17 380 ± 12
 Systolic blood pressure (mmHg) 139 ± 4 205 ± 18** 119 ± 6†††
 Diastolic blood pressure (mmHg) 108 ± 3 138 ± 11** 90 ± 6††
 Mean arterial pressure (mmHg) 125 ± 4 189 ± 6*** 106 ± 6†††
 dP/dtmax (mmHg/s) 10,870 ± 776 14,739 ± 1468* 11,342 ± 924
 dP/dtmin (mmHg/s) −10,593 ± 710 −10,570 ± 1509 −10,556 ± 836
 Tau (ms) 14 ± 1 18 ± 1* 13 ± 1††
 LVEDP (mmHg) 10.8 ± 0.9 17.1 ± 1.8** 11.4 ± 0.7
Cardiac fibrosis
 Interstitial (%) 2.5 ± 0.33 8.9 ± 1.8* 3.6 ± 0.2
 Perivascular (%) 23 ± 2 27 ± 2 28 ± 2
  1. Data are presented as mean ± SEM. Control vs. STNx-vehicle (disease effect) *P < 0.05, **P < 0.01, ***P <0.001; STNx-vehicle vs. ramipril (treatment effect) P < 0.05, ††P < 0.01, †††P < 0.001
  2. Abbreviations: LVDEP left ventricular end diastolic pressure