Fig. 2
From: Case report: a thiazide diuretic to treat polyuria induced by tolvaptan
eGFR over time. Tolvaptan has a hemodynamic effect on eGFR (as calculated by the CKD-EPI formula) that occurs acutely after start of the drug, that is reversible after stopping (as can be seen in 2011). After hydrochlorothiazide (HCT) was started in 2015 the rate of eGFR decline seems steeper. Separate trend lines are shown for eGFR decline on tolvaptan monotherapy and for eGFR decline on tolvaptan-HCT combination therapy