Characteristics | TAC group (n = 33) | TAC + MP group (n = 24) | TAC + TWG group (n = 21) | P value |
---|---|---|---|---|
Sex (male/female) | 13/20 | 14/10 | 9/12 | 0.35 |
Age (years) | 40(21) | 40(26) | 50(22) | 0.16 |
42.00 ± 15.25 | 43.29 ± 14.59 | 49.43 ± 11.89 |  | |
BMI (kg/m2) | 25.30(4.85) | 24.85(5.82) | 23.70(5.10) | 0.37 |
25.82 ± 5.38 | 25.91 ± 3.59 | 24.85 ± 5.05 |  | |
Systolic BP (mmHg) | 129.15 ± 15.38 | 131.00 ± 15.65 | 131.00 ± 20.48 | 0.93 |
Diastolic BP (mmHg) | 71.73 ± 16.77 | 71.83 ± 16.14 | 69.29 ± 15.51 | 0.62 |
Daily urinary protein (g/24Â h) | 6.07(2.43) | 7.38(2.87) | 5.92(2.19) | 0.387 |
6.95 ± 2.43 | 7.25 ± 1.61 | 6.61 ± 1.34 |  | |
Serum albumin (g/L) | 26.13 ± 3.31 | 26.07 ± 2.81 | 25.10 ± 3.55 | 0.64 |
Concentrations of anti-PLA2R antibodies (RU/mL) | 571.00 (215.00) | 571.5(61.25) | 641.69(98.00) | 0.018* |
Anti-PLA2R (positive/negative) | 32/1 | 23/1 | 20/1 | 1 |
Scr (μmol/L) | 72.38 ± 19.78 | 77.28 ± 23.82 | 69.19 ± 15.53 | 0.57 |
BUN (mmol/L) | 5.37 ± 1.97 | 6.46 ± 2.88 | 6.00 ± 1.78 | 0.16 |
UA (μmol/L) | 358.28 ± 128.60 | 326.81 ± 97.13 | 353.62 ± 110.70 | 0.47 |
eGFR (ml/min/1.73 m2) | 97.58 ± 25.51 | 97.44 ± 24.48 | 98.40 ± 15.85 | 0.99 |
Hb (g/L) | 128.79 ± 16.42 | 129.67 ± 17.37 | 131.33 ± 22.04 | 0.89 |
PLT (10^9/L) | 252.58 ± 63.37 | 257.88 ± 60.62 | 233.86 ± 57.8 | 0.39 |
WBC (10^9/L) | 7.28 ± 1.74 | 6.97 ± 1.60 | 6.70 ± 1.86 | 0.49 |
Tch (mmol/L) | 5.67 ± 1.95 | 6.13 ± 2.65 | 5.56 ± 0.89 | 0.62 |
TG (mmol/L) | 1.77 ± 2.04 | 2.41 ± 1.76 | 2.08 ± 0.85 | 0.26 |
LDL (mmol/L) | 3.57 ± 1.19 | 4.46 ± 2.02 | 3.59 ± 1.02 | 0.32 |
HDL (mmol/L) | 1.50 ± 0.60 | 1.55 ± 0.56 | 1.55 ± 0.73 | 0.97 |
Blood glucose (mg/dL) | 5.10 ± 0.61 | 4.9 ± 0.84 | 6.08 ± 2.38 | 0.37 |
Conservative treatment time (months) # | 5.00(4.50) | 8.00(5.00) | 9.00(13.00) | 0.06 |
6.79 ± 2.25 | 8.54 ± 2.70 | 9.71 ± 5 .60 |  | |
ALT (U/L) | 31.33 ± 5.12 | 33.78 ± 8.01 | 31.82 ± 5.27 | 0.33 |
AST (U/L) | 15.72 ± 4.47 | 17.94 ± 10.75 | 18.13 ± 4.70 | 0.16 |
Glomerular stage at renal biopsy (I/I-II/II/II-III/III) | 16/4/8/5 | 11/8/4/1 | 9/4/7/1 | 0.75 |
interstitial fibrosis and tubular atrophy (score) | 1.00(1.00) | 1.00(1.00) | 1.00(1.00) | 0.77 |
0.85 ± 0.87 | 0.67 ± 0.48 | 0.62 ± 0,50 |  | |
Vascular sclerosis (score) | 1.00(2.00) | 1.00 (2.00) | 0.00(2.00) | 0.68 |
0.91 ± 0,95 | 1.00 ± 1, 02 | 0.76 ± 1.14 |  | |
Immunohistological staining | ||||
IgG (score) | 2.00(1.50) | 2.00(0.75) | 2.00(2.00) | 0.86 |
1.49 ± 0.87 | 1.63 ± 0.71 | 1.43 ± 0.93 |  | |
IgG1 (score) | 0.00(0.00) | 0.00(1.00) | 0.00(1.00) | 0.41 |
0.21 ± 0.55 | 0.33 ± 0.57 | 0.38 ± 0.67 |  | |
IgG4 (score) | 0.00(0.00) | 0.00(1.00) | 0.00(1.00) | 0.43 |
0.24 ± 0.61 | .0.38 ± 0.65 | 0.43 ± 0.75 |  | |
C3 (score) | 1.00(1.00) | 1.00(1.00) | 0.00(1.00) | 0.09 |
0.73 ± 0.76 | 0.71 ± 0.46 | 0.38 ± 0.59 |  | |
C4 (score) | 0.00(0.00) | 0.00(0.00) | 0.00(0.00) | 0.83 |
0.13 ± 0.42 | 0.08 ± 0.28 | 0.48 ± 0.22 |  | |
C1q (score) | 0.00(0.00) | 0.00(0.00) | 0.00(0.00) | 0.31 |
0.09 ± 0.30 | 0.13 ± 0.45 | 0.19 ± 0.51 |  | |
Fib (score) | 0.00(0.00) | 0.00(0.00) | 0.00(0.00) | 0.86 |
0.06 ± 0.24 | 0.08 ± 0.28 | 0.05 ± 0.22 |  | |
lgM (score) | 0.00(0.00) | 0.00(0.00) | 0.00(0.00) | 0.32 |
0.03 ± 0.17 | 0.08 ± 0.36 | 0.14 ± 0.36 |  | |
IgA (score) | 0.00(0.00) | 0.00(0.00) | 0.00(0.00) | 0.99 |
0.12 ± 0.42 | 0.08 ± 0.26 | 0.10 ± 0.30 |  |