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Table 1 Baseline characteristics of the patients in the three groups

From: Retrospective analysis of tacrolimus combined with Tripterygium wilfordii polyglycoside for treating idiopathic membranous nephropathy

Characteristics

TAC group (n = 33)

TAC + MP group (n = 24)

TAC + TWG group (n = 21)

P value

Sex (male/female)

13/20

14/10

9/12

0.35

Age (years)

40(21)

40(26)

50(22)

0.16

42.00 ± 15.25

43.29 ± 14.59

49.43 ± 11.89

 

BMI (kg/m2)

25.30(4.85)

24.85(5.82)

23.70(5.10)

0.37

25.82 ± 5.38

25.91 ± 3.59

24.85 ± 5.05

 

Systolic BP (mmHg)

129.15 ± 15.38

131.00 ± 15.65

131.00 ± 20.48

0.93

Diastolic BP (mmHg)

71.73 ± 16.77

71.83 ± 16.14

69.29 ± 15.51

0.62

Daily urinary protein (g/24 h)

6.07(2.43)

7.38(2.87)

5.92(2.19)

0.387

6.95 ± 2.43

7.25 ± 1.61

6.61 ± 1.34

 

Serum albumin (g/L)

26.13 ± 3.31

26.07 ± 2.81

25.10 ± 3.55

0.64

Concentrations of anti-PLA2R antibodies (RU/mL)

571.00 (215.00)

571.5(61.25)

641.69(98.00)

0.018*

Anti-PLA2R (positive/negative)

32/1

23/1

20/1

1

Scr (μmol/L)

72.38 ± 19.78

77.28 ± 23.82

69.19 ± 15.53

0.57

BUN (mmol/L)

5.37 ± 1.97

6.46 ± 2.88

6.00 ± 1.78

0.16

UA (μmol/L)

358.28 ± 128.60

326.81 ± 97.13

353.62 ± 110.70

0.47

eGFR (ml/min/1.73 m2)

97.58 ± 25.51

97.44 ± 24.48

98.40 ± 15.85

0.99

Hb (g/L)

128.79 ± 16.42

129.67 ± 17.37

131.33 ± 22.04

0.89

PLT (10^9/L)

252.58 ± 63.37

257.88 ± 60.62

233.86 ± 57.8

0.39

WBC (10^9/L)

7.28 ± 1.74

6.97 ± 1.60

6.70 ± 1.86

0.49

Tch (mmol/L)

5.67 ± 1.95

6.13 ± 2.65

5.56 ± 0.89

0.62

TG (mmol/L)

1.77 ± 2.04

2.41 ± 1.76

2.08 ± 0.85

0.26

LDL (mmol/L)

3.57 ± 1.19

4.46 ± 2.02

3.59 ± 1.02

0.32

HDL (mmol/L)

1.50 ± 0.60

1.55 ± 0.56

1.55 ± 0.73

0.97

Blood glucose (mg/dL)

5.10 ± 0.61

4.9 ± 0.84

6.08 ± 2.38

0.37

Conservative treatment time (months) #

5.00(4.50)

8.00(5.00)

9.00(13.00)

0.06

6.79 ± 2.25

8.54 ± 2.70

9.71 ± 5 .60

 

ALT (U/L)

31.33 ± 5.12

33.78 ± 8.01

31.82 ± 5.27

0.33

AST (U/L)

15.72 ± 4.47

17.94 ± 10.75

18.13 ± 4.70

0.16

Glomerular stage at renal biopsy (I/I-II/II/II-III/III)

16/4/8/5

11/8/4/1

9/4/7/1

0.75

interstitial fibrosis and tubular atrophy (score)

1.00(1.00)

1.00(1.00)

1.00(1.00)

0.77

0.85 ± 0.87

0.67 ± 0.48

0.62 ± 0,50

 

Vascular sclerosis (score)

1.00(2.00)

1.00 (2.00)

0.00(2.00)

0.68

0.91 ± 0,95

1.00 ± 1, 02

0.76 ± 1.14

 

Immunohistological staining

IgG (score)

2.00(1.50)

2.00(0.75)

2.00(2.00)

0.86

1.49 ± 0.87

1.63 ± 0.71

1.43 ± 0.93

 

IgG1 (score)

0.00(0.00)

0.00(1.00)

0.00(1.00)

0.41

0.21 ± 0.55

0.33 ± 0.57

0.38 ± 0.67

 

IgG4 (score)

0.00(0.00)

0.00(1.00)

0.00(1.00)

0.43

0.24 ± 0.61

.0.38 ± 0.65

0.43 ± 0.75

 

C3 (score)

1.00(1.00)

1.00(1.00)

0.00(1.00)

0.09

0.73 ± 0.76

0.71 ± 0.46

0.38 ± 0.59

 

C4 (score)

0.00(0.00)

0.00(0.00)

0.00(0.00)

0.83

0.13 ± 0.42

0.08 ± 0.28

0.48 ± 0.22

 

C1q (score)

0.00(0.00)

0.00(0.00)

0.00(0.00)

0.31

0.09 ± 0.30

0.13 ± 0.45

0.19 ± 0.51

 

Fib (score)

0.00(0.00)

0.00(0.00)

0.00(0.00)

0.86

0.06 ± 0.24

0.08 ± 0.28

0.05 ± 0.22

 

lgM (score)

0.00(0.00)

0.00(0.00)

0.00(0.00)

0.32

0.03 ± 0.17

0.08 ± 0.36

0.14 ± 0.36

 

IgA (score)

0.00(0.00)

0.00(0.00)

0.00(0.00)

0.99

0.12 ± 0.42

0.08 ± 0.26

0.10 ± 0.30

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