Fig. 8From: Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activityMechanism by which Ang II induces apoptosis in podocytes. AT1R signaling induces ER stress through increased GRP 78 and p-elf2α expression and PKC-δ phosphorylation. p38 MAPK and PKC-δ activation lead to increased Bax expression and enhanced NHE1 activity, triggering cellular apoptosis. Cariporide, NHE1 inhibitor; Losartan, AT1R antagonist; SB203580, p38 MAPK inhibitor; GBM, glomerular basement membraneBack to article page