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Fig. 8 | BMC Nephrology

Fig. 8

From: Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity

Fig. 8

Mechanism by which Ang II induces apoptosis in podocytes. AT1R signaling induces ER stress through increased GRP 78 and p-elf2α expression and PKC-δ phosphorylation. p38 MAPK and PKC-δ activation lead to increased Bax expression and enhanced NHE1 activity, triggering cellular apoptosis. Cariporide, NHE1 inhibitor; Losartan, AT1R antagonist; SB203580, p38 MAPK inhibitor; GBM, glomerular basement membrane

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