Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity

Table 2 pHi recovery rate in control and treated podocytes

	dpHi/dt (Units/min)	n
NMDG, 138 mM	0.045 ± 0.006	11
Control solution, Na⁺ 138 mM, added after NMDG solution	0.179 ± 0.025^a	11
Control solution, Na⁺ 138 mM	0.176 ± 0.016	10
AII 1 μM	0.372 ± 0.028^c	10
Losartan (1 μM)	0.220 ± 0.017	11
AII/Losartan (1 μM)	0.217 ± 0.029^d	8
Cariporide (10 μM)	0.061 ± 0.006^b	6
AII/Cariporide (10 μM)	0.067 ± 0.005 ^db	10
SB203580 (0.1 μM)	0.177 ± 0.023	6
AII/ SB203580 (0.1 μM)	0.217 ± 0.036^e	7

Values are mean ± SEM. n, number of experiments. ^ap < 0.001 versus NMDG (N-methyl-D-glucamine); ^bp < 0.001 versus control; ^cp < 0.001 versus control; ^dp < 0.001 versus angiotensin II (AII) and ^e p < 0.01 versus AII

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