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Fig. 2 | BMC Nephrology

Fig. 2

From: Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts

Fig. 2

Pathological findings of 3 consecutive renal allograft biopsies in Patient 2. In the 1st allograft biopsy, only mild mesangial proliferation were seen (a, PAS × 400). No fuchsinophilic immune-complexes were found (b, Masson× 400). EM was normal with no obvious electron-dense deposits noticed (c). In the 2nd allograft biopsy that was performed 12 months later, LM only revealed mild to moderate mesangial proliferation (d, PAS × 400). Still, no fuchsinophilic immune-complexes could be observed (e, Masson× 400). Nevertheless, IF showed bright granular staining for IgG (subcalss IgG3) and kappa predominantly in the mesangium (f-h). EM revealed obviously electron-dense deposits mainly in the mesangium (i). A 3rd biopsy performed 36 months after the 2nd biopsy demonstrated MPGN pattern and crescents (j, PAS × 400) and obvious fuchsinophilic immune-complexes (k, Masson× 400). In addition to similar IF findings with the 2nd biopsy, positive staining for C1q was also present (l-o). EM (p) showed extensive electron-dense deposits in the subendothelium and mesangium

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