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Table 1 Summary of demographics, clinical features, laboratory workups in 5 included patients

From: Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts

Patient 1 2 3 4 5
  Pre-KT Post-KT 1st post-KT biopsy 2nd post-KT biopsy 3rd post-KT biopsy Post-KT Post-KT 1st post-KT biopsy 2nd post-KT biopsy
Sex/Age M/38 M/41 M/44 M/45 M/48 F/30 M/51 M/51 M/53
Cause of ERSD MPGN (PGNMID) MPGN Unknown Unknown MPGN
Transplant type   DCD DCD DCD Living-related donor DCD
Immunosuppression protocol   Pre + MMF + CsA Pre + MMF + FK506 Pre + MMF + FK506 Pre + MMF + FK506 Pre + MMF + FK506
PRA   I-/II- I-/II- I-/II- I-/II- I+/II- I-/II+ I-/II- I-/II-
Time interval from KT to PGNMID   19 months   15 monthsa 52 months 10.5 months 11 months 5 months 33 months
Scr at biopsy (mg/dL) 9.2 0.77 1.26 1.24 3.05 1.2 1.67 1.88 1.33
Proteinuria at biopsy (g/24 h) 4+ 2.21   2+ 6.09 0.66 5.5 1.3 37.03
Hematuria at biopsy 2+ 3+ ND ND 2+ 3+ 4+ 2+ 3+
Urine C3 (mg/dL) 32.0 8.2 ND ND ND ND 3 ND ND
Serum C3/C4 ND Normal ND ND ND Normal Normal Normal Normal
Serum kappa/lambda ND ND ND Normal Normal 4.2/2.51 mg/L 86.51/68.8 mg/L Normal ND
Cryoglobulin Negative Negative ND Negative Negative Negative Negative Negative ND
C3NeF Negative Negative ND ND ND Negative Negative Negative ND
CFH ND ND ND ND ND Normal Normal Negative ND
CFH antibody ND Negative ND ND ND Negative ND Negative ND
HBV/HCV/HIV Negative Negative Negative Negative Negative Negative Negative HCV+ Negative
Serum M spike ND ND ND Negative Negative Negative Negative Negative Negative
Bone marrow aspirate ND ND ND ND ND Negative Negative Negative Negative
  1. Range: urine C3 < 2.76 mg/dl; serum kappa: 7-23 mg/L; serum lambda: 6-20 mg/L
  2. Abbreviations: C3NeF C3 nephrotic factor, CFH complement factor H, CsA cyclosporin, KT kidney transplantation, MMF mycophenolate mofetil, MPGN membranoproliferative glomerulonephritis, ND not done or not available, PRA panel reactive antibody, Pre predisone, Scr serum creatinine
  3. a: in the 2nd biopsy of case 2, PGNMID was retrospectively diagnosed. The diagnosis at that time was mild mesangial proliferation