Skip to main content

Table 2 Summary of renal pathology findings of 5 included patients

From: Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts

Patient

1

2

3

4

5

 

Pre-KT

Post-KT

1st post-KT biopsy

2nd post-KT biopsy*

3rd post-KT biopsy

Post-KT

Post-KT

1st post-KT biopsy

2nd post-KT biopsy

Microscopic pattern

MPGN

MPGN

Mild mesangial proliferation

Mild mesangial proliferation

MPGN + Crescents

Moderate to severe mesangial proliferation

Diffuse proliferation

Moderate mesangial proliferation

MPGN

Glomeruli sclerosed (%)

24

0

7.6

0

26.7

0

27.8

0

5.3

Crescents (%)

23.8

16.7

0

0

53.3

0

0

3

10.5

IF/TA

Moderate

Mild

No IF/TA

No IF/TA

moderate

Mild

Moderate

Mild

Moderate

IgG isotype

IgG3/kappa

IgG3/kappa

None

IgG3/kappa

IgG3/kappa

IgG3/Lambda

IgG3/Lambda

IgG3/kappa

IgG3/kappa

C3

++

++

++

+++

++

++

++

C1q

++

+

+

+++

++

+

++

Electron-dense deposits

GBM + mesangial

GBM + mesangial

Negative

Mainly mesangial

Subendothelial + mesangial

Subendothelial + mesangial + subepithelial

GBM

GBM + mesangial

GBM + mesangial

  1. Abbreviations: AAMR acute antibody-mediated rejection, GBM glomerular basement membrane, IF/TA interstitial fibrosis and tubular atrophy, KT kidney transplantation, MPGN membranoproliferative glomerulonephritis, PGNMID proliferative glomerulonephritis with monoclonal IgG deposits
  2. *: in the 2nd biopsy of case 2, PGNMID was retrospectively diagnosed. The diagnosis at that time was mild mesangial proliferation