Skip to main content

Advertisement

Table 2 Summary of renal pathology findings of 5 included patients

From: Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts

Patient 1 2 3 4 5
  Pre-KT Post-KT 1st post-KT biopsy 2nd post-KT biopsy* 3rd post-KT biopsy Post-KT Post-KT 1st post-KT biopsy 2nd post-KT biopsy
Microscopic pattern MPGN MPGN Mild mesangial proliferation Mild mesangial proliferation MPGN + Crescents Moderate to severe mesangial proliferation Diffuse proliferation Moderate mesangial proliferation MPGN
Glomeruli sclerosed (%) 24 0 7.6 0 26.7 0 27.8 0 5.3
Crescents (%) 23.8 16.7 0 0 53.3 0 0 3 10.5
IF/TA Moderate Mild No IF/TA No IF/TA moderate Mild Moderate Mild Moderate
IgG isotype IgG3/kappa IgG3/kappa None IgG3/kappa IgG3/kappa IgG3/Lambda IgG3/Lambda IgG3/kappa IgG3/kappa
C3 ++ ++ ++ +++ ++ ++ ++
C1q ++ + + +++ ++ + ++
Electron-dense deposits GBM + mesangial GBM + mesangial Negative Mainly mesangial Subendothelial + mesangial Subendothelial + mesangial + subepithelial GBM GBM + mesangial GBM + mesangial
  1. Abbreviations: AAMR acute antibody-mediated rejection, GBM glomerular basement membrane, IF/TA interstitial fibrosis and tubular atrophy, KT kidney transplantation, MPGN membranoproliferative glomerulonephritis, PGNMID proliferative glomerulonephritis with monoclonal IgG deposits
  2. *: in the 2nd biopsy of case 2, PGNMID was retrospectively diagnosed. The diagnosis at that time was mild mesangial proliferation