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Table 2 Prevalence of seronegative results

From: Varicella infections in patients with end stage renal disease: a systematic review

Reference Main Results Timing of serology taken Main conclusions Study quality
Renal transplant patients/recipients Haemodialysis patients Renal transplant candidates +
Crespo JF, et al. (2002) [16]    Among 336 renal transplant candidates, 33 (9.8%) were seronegative. Before contraction of primary varicella Level 2
Geel AL, et al. (2006) [17] Among 854 transplant recipients,
2.1% were seronegative.
  Among 286 patients on the wait list, 3.2% patients were seronegative Before contraction of primary varicella -Low prevalence of seronegativity.
-At risk of severe complications after contact with chickenpox.
Level 2
Rodríguez-Moreno A, et al. (2006) [13] Among the four patients that developed primary varicella infection, all were tested negative for VZV IgG.    Presentation/onset of primary varicella -Varicella infection among renal allograft recipients is unusual but carries a high morbidity and mortality. Level 3
Kaul A, et al. (2012) [9] Among 23 renal allograft patients that developed varicella infection, all was tested negative for VZV IgG.    Presentation/onset of primary varicella Level 3
Talebi-Taher M, et al. (2013) [18]   Among 187 patients on haemodialysis, 2.1% were seronegative.   Before contraction of primary varicella -No correlation between patient’s self-reported history of VZV infection and seroprevalence status (p = 0.6).
-Serologic screening for VZV for transplant candidates is essential.
-Consider this population as a target group for future national immunisation program.
Level 2
Abad CL, et al. (2016) [14] Among 54 cases of varicella in transplant recipients, baseline serology available in 32 patients,
19 (59.4%) were seronegative.
   Presentation/onset of primary varicella Baseline serologies before transplantation remains useful as markers for prior exposure and latent infection.
It also guides VZV vaccination.
Level 3
Ong CY, et al. (2018) [15] Among 66 cases of varicella in patients with ESRD (dialysis, transplant, conservative), baseline serology available in 19 patients. 42.1% were seronegative. Presentation/onset of primary varicella -Immunity to varicella should be screened among ESRD patients.
-Seronegative patients to be considered for varicella vaccination.
Level 3
  1. + Information on whether renal replacement or no renal replacement therapy given while awaiting transplant were not mentioned