From: Varicella infections in patients with end stage renal disease: a systematic review
Reference | Number of patients studied | Number of dose of VZV vaccine | Seroconversion rate/response rate | Main conclusions | Study quality |
---|---|---|---|---|---|
Crespo JF, et al. (2002) [16] | 17 | 2 | -94.1% after second dose of VZV vaccination. | -Vaccination protocol is effective in seroconverting. | Level 2 |
Geel AL, et al. (2006) [17] | 11 | 2 | -64% seroconverted after two doses of VZV vaccine. | -64% seroconversion was lesser than post-licensure studies. -Impaired immune system was responsible for less ability to mount antibody titres and maintaining it over time. | Level 2 |
Kho MM, et al. (2016) [32] | 52 | 2 | -40 responders (77%) found (AUC > 0.9) VZV specific antibody (Ab) at 3 months. -At one year, 67% still have positive VZV Ab. -At two years,45.8% have positive VZV Ab | -Two-dose vaccination before kidney transplantation regime is safe and effective in adults with CKD, resulting at least 77% seroconversion in VZV IgG and VZV-specific T cell memory. | Level 2 |