|Reference||Number of patients studied||Number of dose of VZV vaccine||Seroconversion rate/response rate||Main conclusions||Study quality|
|Crespo JF, et al. (2002) ||17||2||-94.1% after second dose of VZV vaccination.||-Vaccination protocol is effective in seroconverting.||Level 2|
|Geel AL, et al. (2006) ||11||2||-64% seroconverted after two doses of VZV vaccine.||
-64% seroconversion was lesser than post-licensure studies.|
-Impaired immune system was responsible for less ability to mount antibody titres and maintaining it over time.
|Kho MM, et al. (2016) ||52||2||
-40 responders (77%) found (AUC > 0.9) VZV specific antibody (Ab) at 3 months.|
-At one year, 67% still have positive VZV Ab.
-At two years,45.8% have positive VZV Ab
|-Two-dose vaccination before kidney transplantation regime is safe and effective in adults with CKD, resulting at least 77% seroconversion in VZV IgG and VZV-specific T cell memory.||Level 2|