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Table 4 Immunogenicity of varicella vaccination

From: Varicella infections in patients with end stage renal disease: a systematic review

Reference

Number of patients studied

Number of dose of VZV vaccine

Seroconversion rate/response rate

Main conclusions

Study quality

Crespo JF, et al. (2002) [16]

17

2

-94.1% after second dose of VZV vaccination.

-Vaccination protocol is effective in seroconverting.

Level 2

Geel AL, et al. (2006) [17]

11

2

-64% seroconverted after two doses of VZV vaccine.

-64% seroconversion was lesser than post-licensure studies.

-Impaired immune system was responsible for less ability to mount antibody titres and maintaining it over time.

Level 2

Kho MM, et al. (2016) [32]

52

2

-40 responders (77%) found (AUC > 0.9) VZV specific antibody (Ab) at 3 months.

-At one year, 67% still have positive VZV Ab.

-At two years,45.8% have positive VZV Ab

-Two-dose vaccination before kidney transplantation regime is safe and effective in adults with CKD, resulting at least 77% seroconversion in VZV IgG and VZV-specific T cell memory.

Level 2