Table 1 Baseline characteristics of subjects by uric acid quartiles (Q1-Q4) at baseline (male)

N

3176

817

794

718

847

Age (years)

48 (24)

48 (26)

44 (22)

47 (23)

50 (23)

0.001

BMI (kg/m²)

24.0±2.9

22.8±2.8

23.7±2.7

24.3±2.8

25.0±2.9

< 0.001

Overweight (24 ≤ BMI < 28) (%)

1329 (41.8)

233 (28.5)

311 (39.2)

332 (46.2)

453 (53.5)

< 0.001

Obesity (BMI ≥ 28) (%)

249 (7.8)

33 (4.0)

41 (5.2)

67 (9.3)

108 (12.8)

< 0.001

Systolic BP (mmHg)

128.6±17.4

126.9±17.7

127.2±17.2

129.3±17.5

130.9±16.8

< 0.001

Diastolic BP (mmHg)

78.0±10.8

76.2±10.8

77.2±11.1

78.6±10.4

79.9±10.7

< 0.001

Total cholesterol (mmol/L)

4.8±0.9

4.7±0.9

4.7±0.9

4.8±0.9

5.0±0.9

< 0.001

Triglycerides (mmol/L)

1.6±1.3

1.3±1.2

1.4±1.0

1.6±1.0

2.0±1.7

< 0.001

HDL cholesterol (mmol/L)

1.2±0.3

1.3±0.3

1.2±0.2

1.2±0.2

1.1±0.2

< 0.001

LDL cholesterol (mmol/L)

2.8±0.7

2.7±0.7

2.8±0.7

2.9±0.8

2.9±0.8

< 0.001

BUN (mmol/L)

5.2±1.1

5.1±1.2

5.2±1.1

5.3±1.1

5.3±1.1

0.031

Fasting plasma glucose (mmol/L)

5.3±0.9

5.3±1.1

5.2±0.8

5.3±0.9

5.3±0.8

0.019

eGFR (ml/min/1.73m²)

84.9±13.7

88.2±13.7

86.2±13.7

84.9±13.9

80.6±12.3

< 0.001

Serum uric acid (mg/dl)

6.3±1.2

4.9±0.5

5.9±0.2

6.5±0.2

7.7±0.7

< 0.001

Hypertension (%)

560 (17.6)

125 (15.3)

114 (14.4)

137 (19.1)

184 (21.7)

Diabetes (%)

136 (4.3)

43 (5.3)

30 (3.8)

27 (3.8)

36 (4.3)

0.409

New incident CKD (%)

139 (4.4)

22 (2.7)

22 (2.8)

31 (4.3)

64 (7.6)

< 0.001