Table 2 Baseline characteristics of subjects by uric acid quartiles (Q1-Q4) at baseline (female)

N

2007

548

440

524

495

Age (years)

49 (22)

45 (18)

46 (19)

48 (23)

58 (25)

< 0.001

BMI (kg/m²)

22.1±2.8

21.1±2.6

21.7±2.5

22.1±2.7

23.5±3.1

< 0.001

Overweight (24 ≤ BMI < 28) (%)

402 (20.0)

73 (13.3)

62 (14.1)

99 (18.9)

168 (33.9)

< 0.001

Obesity (BMI ≥ 28) (%)

62 (3.1)

5 (0.9)

6 (1.4)

16 (3.1)

35 (7.1)

< 0.001

Systolic BP (mmHg)

120.6±19.1

116.4±17.2

118.3±16.9

120.1±19.3

128.0±20.9

< 0.001

Diastolic BP (mmHg)

71.7±11.0

69.8±10.2

70.9±10.6

71.5±10.7

74.7±11.8

< 0.001

Total cholesterol (mmol/L)

4.9±0.9

4.7±0.9

4.8±0.9

4.9±0.9

5.2±1.0

< 0.001

Triglycerides (mmol/L)

1.2±0.8

1.0±0.6

1.0±0.5

1.2±0.9

1.5±1.0

< 0.001

HDL cholesterol (mmol/L)

1.5±0.3

1.5±0.3

1.5±0.3

1.4±0.3

1.4 ±0.3

< 0.001

LDL cholesterol (mmol/L)

2.8±0.8

2.6±0.7

2.7±0.7

2.8±0.8

3.0±0.8

< 0.001

BUN (mmol/L)

4.7±1.1

4.5±1.1

4.6±1.1

4.6±1.1

5.0±1.1

< 0.001

Fasting plasma glucose (mmol/L)

5.1±0.7

5.0±0.6

5.1±0.6

5.1±0.6

5.3±0.8

< 0.001

eGFR (ml/min/1.73m²)

88.3±17.4

92.7±17.8

89.4±17.7

88.3±17.1

82.4±15.2

< 0.001

Serum uric acid (mg/dl)

4.7±1.0

3.5±0.4

4.3±0.1

4.8±0.2

5.9±0.6

< 0.001

Hypertension (%)

288 (14.3)

39 (7.1)

49 (11.1)

75 (14.3)

126 (25.5)

< 0.001

Diabetes (%)

61 (3.0)

5 (0.9)

14 (3.2)

16 (3.1)

27 (5.5)

< 0.001

New incident CKD (%)

88 (4.4%)

9 (1.6%)

11 (2.5%)

21 (4.0%)

47 (9.5%)

< 0.001