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Table 3 Clinical characteristics of kidney receptors

From: Molecular profile of urine extracellular vesicles from normo-functional kidneys reveal minimal differences between living and deceased donors

Donor uEV Analysis Cold ischemia (hours) Mismatch Recipient’s previous KTx DSA IS Delay Graft function ACR CHR KB Days until stable Renal function SrCr (mg/dL) 1 year After KTx
A B DR
LD1 P, T 2 0 0 0 1 P, B, FK, MMf 5 1
LD2 P, T 2 1 1 1 P, B, FK, MMf 6 1.2
LD3 P, T 2 1 1 2 P, B, FK, MMf 8 1.14
LD4 P, T 2 1 1 1 P, B, FK, MMf Yes Yes ACR
LD5 P, T 4 1 2 1 P, B, FK, MMf       
DD1 P, T 20 2 2 1 P, FK, MMf 14 1,82
Not transplanted             
DD2 P,T 18 2 2 1 P, B, FK, MMf 20 1.77
22 0 0 1 P, B, FK, MMf 15 1.23
DD3 P,T 18 1 1 1 P, FK, Th, Everolimus 7 1.45
Not transplanted             
DD4 T 20 1 1 1 P, B, FK, MMf CNTI 15 1.67
15 1 2 1 P, B, FK, MMf ATN, TAIF 6 2.6
DD5 T 20 1 2 2 P, B, FK, MMf 9 1.64
17 1 1 1 Eculizumab, P, FK, MMF, Th 24 1.39
DD6 P 13 2 2 1 P, B, FK, MMf Yes ACR 24 1.03
22 1 1 1 Yes P,FK; MMf, Th 25 1.16
DD7 P 17 2 2 1 P, B, FK, MMf Yes 30 1.01
20 1 1 1 P, B, FK, MMf 30 1.01
  1. A summary of the HLA-mismatch, donor specific antibodies (DSA), cold ischemia time, previous transplants, immunosuppression treatment, delay graft function and renal biopsy are provided. P: sample used for proteomic assays. T: sample used for transcriptomic NGS assays
  2. KTx Kidney transplantation, DSA donor specific antibodies, IS immunosuppression treatment, ACR acute cellular rejection, CHR chronic humoral rejection, KB kidney biopsy, P Prednisone, FK Tacrolimus, MMf mycophenolate mofetil, B Basiliximab, Th Thymoglobulin, ATN Acute tubular necrosis, CNIT calcineurin inhibitor toxicity, TAIF tubular atrophy and interstitial fibrosis, AS arteriosclerosis