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Table 3 Clinical characteristics of kidney receptors

From: Molecular profile of urine extracellular vesicles from normo-functional kidneys reveal minimal differences between living and deceased donors

Donor

uEV Analysis

Cold ischemia (hours)

Mismatch

Recipient’s previous KTx

DSA

IS

Delay Graft function

ACR

CHR

KB

Days until stable Renal function

SrCr (mg/dL) 1 year After KTx

A

B

DR

LD1

P, T

2

0

0

0

1

P, B, FK, MMf

5

1

LD2

P, T

2

1

1

1

P, B, FK, MMf

6

1.2

LD3

P, T

2

1

1

2

P, B, FK, MMf

8

1.14

LD4

P, T

2

1

1

1

P, B, FK, MMf

Yes

Yes

ACR

LD5

P, T

4

1

2

1

P, B, FK, MMf

      

DD1

P, T

20

2

2

1

P, FK, MMf

14

1,82

Not transplanted

            

DD2

P,T

18

2

2

1

P, B, FK, MMf

20

1.77

22

0

0

1

P, B, FK, MMf

15

1.23

DD3

P,T

18

1

1

1

P, FK, Th, Everolimus

7

1.45

Not transplanted

            

DD4

T

20

1

1

1

P, B, FK, MMf

CNTI

15

1.67

15

1

2

1

P, B, FK, MMf

ATN, TAIF

6

2.6

DD5

T

20

1

2

2

P, B, FK, MMf

9

1.64

17

1

1

1

Eculizumab, P, FK, MMF, Th

24

1.39

DD6

P

13

2

2

1

P, B, FK, MMf

Yes

ACR

24

1.03

22

1

1

1

Yes

P,FK; MMf, Th

25

1.16

DD7

P

17

2

2

1

P, B, FK, MMf

Yes

30

1.01

20

1

1

1

P, B, FK, MMf

30

1.01

  1. A summary of the HLA-mismatch, donor specific antibodies (DSA), cold ischemia time, previous transplants, immunosuppression treatment, delay graft function and renal biopsy are provided. P: sample used for proteomic assays. T: sample used for transcriptomic NGS assays
  2. KTx Kidney transplantation, DSA donor specific antibodies, IS immunosuppression treatment, ACR acute cellular rejection, CHR chronic humoral rejection, KB kidney biopsy, P Prednisone, FK Tacrolimus, MMf mycophenolate mofetil, B Basiliximab, Th Thymoglobulin, ATN Acute tubular necrosis, CNIT calcineurin inhibitor toxicity, TAIF tubular atrophy and interstitial fibrosis, AS arteriosclerosis