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Table 2 Results of meta-analysis comparison of off-clamp partial nephrectomy and on-clamp partial nephrectomy

From: Off-clamp partial nephrectomy has a positive impact on short- and long-term renal function: a systematic review and meta-analysis

Outcomes of interest Studies, no off-PN patients, no on-PN patient, no WMD/OR (95%CI) p value Study heterogeneity
Chi2 df p value I2,%
Primary outcomes
 short-term change of eGFR 10 340 927 4.81(3.53,6.08) < 0.00001 9.65 9 0.38 7
 short-term change of Cr level 10 270 536 −0.05(− 0.09,-0.00) 0.04 9.29 9 0.41 3
 long-term change of eGFR 11 745 1296 1.26(0.04,2.48) 0.04 16.63 10 0.08 40
 long-term % change of eGFR 8 673 1166 2.52(1.53,3.50) < 0.00001 1.13 7 0.99 0
 long-term change of Cr level 3 250 351 −0.04(−0.13, 0.05) 0.40 5.47 2 0.07 63
Secondary outcomes
 long-term eGFR 9 582 1040 −0.18(−3.89,3.53) 0.92 37.54 8 < 0.00001 79
 short-term eGFR 9 327 915 9.72(6.13,13.30) < 0.00001 43.70 8 < 0.00001 82
 short-term Cr level 7 237 452 −0.08(−0.13,-0.02) 0.007 2.23 6 0.90 0
 increase in CKD(stage≥3) 5 170 522 0.73(0.39,1.39)a 0.34 0.97 4 0.91 0
 postoperative AFR 3 224 568 0.25(0.10,0.63)a 0.003 0.10 2 0.95 0
  1. off-PN = off-clamp partial nephrectomy; on-PN = on-clamp partial nephrectomy; WMD/OR = weighted mean difference/odds ratio; df = degrees of freedom; CI = confidence interval; eGFR = estimated glomerular filtration rate; Cr = serum creatinine
  2. CKD chronic kidney disease, AFR acute renal failure
  3. aOdds ratio