Off-clamp partial nephrectomy has a positive impact on short- and long-term renal function: a systematic review and meta-analysis

Table 2 Results of meta-analysis comparison of off-clamp partial nephrectomy and on-clamp partial nephrectomy

Outcomes of interest	Studies, no	off-PN patients, no	on-PN patient, no	WMD/OR (95%CI)	p value	Study heterogeneity
Outcomes of interest	Studies, no	off-PN patients, no	on-PN patient, no	WMD/OR (95%CI)	p value	Chi²	df	p value	I²,%
Primary outcomes
short-term change of eGFR	10	340	927	4.81(3.53,6.08)	< 0.00001	9.65	9	0.38	7
short-term change of Cr level	10	270	536	−0.05(− 0.09,-0.00)	0.04	9.29	9	0.41	3
long-term change of eGFR	11	745	1296	1.26(0.04,2.48)	0.04	16.63	10	0.08	40
long-term % change of eGFR	8	673	1166	2.52(1.53,3.50)	< 0.00001	1.13	7	0.99	0
long-term change of Cr level	3	250	351	−0.04(−0.13, 0.05)	0.40	5.47	2	0.07	63
Secondary outcomes
long-term eGFR	9	582	1040	−0.18(−3.89,3.53)	0.92	37.54	8	< 0.00001	79
short-term eGFR	9	327	915	9.72(6.13,13.30)	< 0.00001	43.70	8	< 0.00001	82
short-term Cr level	7	237	452	−0.08(−0.13,-0.02)	0.007	2.23	6	0.90	0
increase in CKD(stage≥3)	5	170	522	0.73(0.39,1.39)^a	0.34	0.97	4	0.91	0
postoperative AFR	3	224	568	0.25(0.10,0.63)^a	0.003	0.10	2	0.95	0

off-PN = off-clamp partial nephrectomy; on-PN = on-clamp partial nephrectomy; WMD/OR = weighted mean difference/odds ratio; df = degrees of freedom; CI = confidence interval; eGFR = estimated glomerular filtration rate; Cr = serum creatinine
CKD chronic kidney disease, AFR acute renal failure
^aOdds ratio

ISSN: 1471-2369