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Table 3 Subgroup analysis and sensitivity analysis of primary outcomes

From: Off-clamp partial nephrectomy has a positive impact on short- and long-term renal function: a systematic review and meta-analysis

Comparison MD (95%CI) p value Study heterogeneity
Chi2 df p value I2,%
short-term change of eGFR 4.81(3.53,6.08) < 0.00001 9.65 9 0.38 7
 Studies (LS) 6.24(3.62,8.86) < 0.00001 5.00 3 0.17 40
 Studies (SS) 4.36(2.91,5.82) < 0.00001 3.14 5 0.68 0
 Exclusion of [35] 4.78(3.31,6.25) < 0.00001 9.65 8 0.29 17
short-term change of Cr level −0.05(−0.09,-0.00) 0.04 9.29 9 0.41 3
 Studies (LS) −0.05(− 0.12,0.01) 0.11 2.29 1 0.13 56
 Studies (SS) −0.04(− 0.11,0.02) 0.20 6.95 7 0.43 0
 Exclusion of [24, 38] −0.08(− 0.14,-0.02) 0.006 5.33 7 0.62 0
long-term change of eGFR 1.26(0.04,2.48) 0.04 16.63 10 0.08 40
 Studies (LS) 2.08(1.55,2.61) < 0.00001 4.63 5 0.46 0
 Studies (SS) −2.57(−5.35, 0.22) 0.07 1.69 4 0.79 0
 Exclusion of [29, 38] 2.02(1.49,2.54) < 0.00001 9.55 8 0.30 16
long-term % change of eGFR 2.45(1.46,3.44) < 0.00001 2.31 7 0.94 0
 Studies (LS) 2.52(1.51,3.52) < 0.00001 1.13 5 0.95 0
 Studies (SS) −0.36(−6.82,6.10) 0.91 0.44 1 0.51 0
 Exclusion of [37] 2.50(1.49,3.50) < 0.00001 1.93 6 0.93 0
long-term change of Cr level − 0.04(− 0.13,0.05) 0.40 5.47 2 0.07  
 Studies (LS) −0.09(− 0.14,-0.04) 0.0002 Not applicable    
 Studies (SS) 0.00(−0.12,0.13) 0.95 2.08 1 0.15 52
 Exclusion of [38] −0.09(− 0.13,-0.04) 0.0002 0.21 1 0.65 0
  1. MD mean difference, CI confidence interval, df degrees of freedom, eGFR estimated glomerular filtration rate, Cr serum creatinine, LS large sample study, SS small sample study