Chronic kidney disease with genitourinary tuberculosis: old disease but ongoing complication

BMC Nephrology

Table 3 Treatment modality and complications of both groups according to kidney function in GUTB patients

Variables	Normal kidney function group (n = 45)	CKD group (n = 11)	Total (n = 56)	p
Medical treatment
TB medication use	42 (93.3)	11 (100.0)	53 (94.6)	0.894
Medication regimen				1.000
HER	6 (13.3)	1 (9.1)	7 (12.5)
HERZ	36 (80.0)	10 (90.9)	46 (82.1)
Medication durations (m)	9 (6–9)	9 (9–10)	9 (6–10)	0.243
Surgical treatment
All surgical techniques^a	32 (71.1)	10 (90.9)	42 (75.0)	0.332
Ablative surgery^b	23 (51.5)	8 (72.7)	31 (55.4)	0.340
Nephrectomy	11 (24.4)	4 (36.4)	15 (26.8)	0.674
Reconstructive therapy^c	12 (26.7)	3 (27.3)	15 (26.8)	1.000
Follow up durations (m)	38.2 ± 27.8	48.0 ± 47.0	40.5 ± 32.5	0.362
Complications
Hydronephrosis	9 (20.0)	3 (27.3)	12 (21.4)	0.038
Bladder contraction	3 (6.7)	2 (18.2)	5 (8.9)	0.021
Renal calcification	10 (22.2)	3 (27.3)	13 (23.2)	0.044
Additional surgical treatment^d	9 (20.0)	6 (54.5)	15 (26.8)	0.005
Recurrence	3 (6.7)	1 (9.1)	4 (7.1)	0.056
All cause mortality	2 (4.4)	2 (18.2)	4 (7.1)	0.132
ESRD development	0 (0.0)	4 (36.4)	4 (7.1)	0.001

Bold values indicate statistically significant differences
Data were presented as mean ± SD, number (percentage) or median (IQR)
GUTB genitourinary tuberculosis, CKD chronic kidney disease, TB tuberculosis, HER isoniazid, rifampicin, and ethambutol, HERZ isoniazid, rifampicin, ethambutol, with pyrazinamide, ESRD end-stage renal disease, SD standard deviation, IQR interquartile range
^aAll surgical techniques included all ablative surgery and reconstructive surgery from the time of diagnosis to completion of medical treatment
^bAblative surgery is associated with partial or total nephrectomy, nephro-ureterectomy, cystectomy, epididymectomy, semicastration, salpingectomy, as well as other procedures
^cReconstructive therapy is considered for: ureteric or urethral stricture repair; stent placement, replacement, or reimplantation; resection; urinary diversion; and bladder augmentation cystoplasty
^dAny surgical treatment during follow up after completed medical treatment

ISSN: 1471-2369